Influence of Hamstrings on Knee Moments During Loading Response of Gait in Individuals Following ACL Reconstruction.

Biomechanical studies consistently report smaller knee extensor moments in the surgical limb during loading response (LR) of gait following ACL reconstruction (ACLr). However, this reduction in knee loading is quantified by net joint moments (NJM). As a result, in the presence of greater hamstring activity, the true contribution from the knee extensors may not be reduced. The purpose of this study is to compare hamstring activity and strength and knee joint moments between individuals post-ACLr and controls. Eighteen individuals 3 months post-ACLr and matched controls walked and net knee extensor moment peak and impulse and hamstring activity were identified during LR, as well as maximal hamstring strength. A hybrid musculoskeletal model estimated knee flexor moments from joint kinematics and hamstring electromyography. Flexor moments (SIMM) were scaled based on strength. Knee extensor moments were estimated from the sum of the net knee moment and estimated knee flexor moment; estimated extensor moment peaks and impulse were calculated during LR. Repeated measures analysis of variance compared groups and limbs. Smaller net knee extensor moment and greater hamstring activity, as well as deficits in maximal hamstring strength, were observed in the surgical limb (all p < 0.05). When accounting for the torque-producing capabilities of the knee flexors, estimated knee extensor moment peak and impulse were smaller in the surgical limb. These findings suggest that net knee moments accurately reflect smaller knee extensor loading post-ACLr. Statement of Clinical Significance: Rehabilitation programs should target increasing knee extensor loading to restore gait mechanics during early rehabilitation. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:378-386, 2020.

Subtle alterations in whole body mechanics during gait following anterior cruciate ligament reconstruction.

BACKGROUND: Clinically, normalization of gait following anterior cruciate ligament reconstruction (ACLr) is defined as the absence of observable deviations. However, biomechanical studies report altered knee mechanics during loading response (LR); a time of double limb support and weight transfer between limbs. It is conceivable that subtle adjustments in whole body mechanics, including center of mass (COM) velocity and ground reaction force (GRF) peaks and timing, are present. RESEARCH QUESTION: The purpose was to compare limb and whole body mechanics during LR of gait in the surgical and non-surgical limbs post-ACLr. METHODS: Anterior and vertical COM velocity at initial contact; knee flexion range of motion, peak knee extensor moment, peak vertical and posterior GRF, minimum vertical COM position and maximum anterior and vertical COM velocity during LR were identified for twenty individuals 112 ± 17 days post-ACLr without observable gait deficits. To assess differences in timing of COM variables, coupling angles (vector coding) were calculated for multidirectional coordination of vertical and anteroposterior COM velocities and GRFs and categorized as in-phase, anti-phase, vertical phase, or anteroposterior phase coordination. Paired t-tests compared peaks between limbs; non-parametric Wilcoxon signed-rank tests compared coordination pattern frequency. RESULTS: Less knee range of motion (5.6 °), 30% smaller knee extensor moment, 11% smaller posterior GRF, and slower anterior COM velocity at initial contact (2%) and peak during LR (1.3%; all p < 0.05) were observed in the surgical compared to the non-surgical limb. For COM velocity coordination, lesser anti-phase (7.38%) and greater in-phase coordination (2.88%) were observed in the surgical limb. For GRF coordination, less in-phase coordination (1.94%) was observed in the surgical limb. SIGNIFICANCE: Differences in coordination patterns, suggest that individuals post-ACLr make subtle adjustments in timing of whole body mechanics; particularly in COM velocity during gait. These adjustments are consistent with reduced sagittal plane loading in the surgical knee.

Contributors to knee loading deficits during gait in individuals following anterior cruciate ligament reconstruction.

BACKGROUND: Altered gait mechanics following anterior cruciate ligament reconstruction (ACLr) are commonly reported in the surgical limb 2-3 months post-surgery when normalization of gait is expected clinically. Specifically, deficits in knee extensor moment during loading response of gait are found to persist long-term; however, the mechanisms by which individuals reduce sagittal plane knee loading during gait are not well understood. RESEARCH QUESTION: This study investigated between limb asymmetries in knee flexion range of motion, shank angular velocity, and ground reaction forces to determine the strongest predictor of knee extensor moment asymmetries during gait. METHODS: Thirty individuals 108 ± 17 days post-ACLr performed walking gait at a self-selected speed and peak knee extensor moment, peak vertical and posterior ground reaction force, and peak anterior shank angular velocity were identified during loading response. Paired t-tests compared limbs; Pearson's correlations determined associations between variables in surgical and non-surgical limbs; and stepwise linear regression determined the best predictor of knee extensor moment asymmetries during gait. RESULTS: Reduced vertical and posterior ground reaction forces and shank angular velocity were strongly associated with reduced knee extensor moment in both limbs (r = 0.499-0.917, p < 0.005). Less knee flexion range of motion was associated with reduced knee moment in the surgical limb (r = 0.358, p < 0.05). Additionally, asymmetries in posterior ground reaction force and knee flexion range of motion predicted asymmetries in knee extensor moment (R2 = 0.473, p < 0.001). SIGNIFICANCE: Modulation of kinetics and kinematics contribute to decreases in knee extensor moments during gait and provide direction for targeted interventions to restore gait mechanics.

Compensatory Strategies That Reduce Knee Extensor Demand During a Bilateral Squat Change From 3 to 5 Months Following Anterior Cruciate Ligament Reconstruction.

Background Decreased extensor moments in the surgical knee during bilateral squats can persist beyond 1 year following anterior cruciate ligament reconstruction (ACLR). This is accomplished using interlimb and intralimb compensations. Objectives This study sought to assess loading during squatting longitudinally, 3 and 5 months post ACLR, and to determine the extent to which interlimb and intralimb compensations contribute to reduced knee extensor moments. Methods In this controlled, longitudinal laboratory study, 11 individuals (4 male) underwent 3-D motion analysis of a squat at 3 and 5 months post ACLR. A repeated-measures multivariate analysis of variance (limb by time) assessed differences in peak knee and hip flexion angles, knee extensor moment, vertical ground reaction force, and hip-to-knee extensor moment ratio. Stepwise linear regression analysis was used to determine the contribution of interlimb (between-limb vertical ground reaction force ratio) and intralimb (within-surgical-limb hip-to-knee moment ratio) compensations to the between-limb knee extensor moment ratio. Results A significant effect of limb was observed for knee flexion angle, knee extensor moment, vertical ground reaction force, and hip-to-knee extensor moment ratio, while a significant effect of time was observed for knee extensor moment and hip-to-knee extensor moment ratio. At 3 months, the vertical ground reaction force ratio and hip-to-knee extensor moment ratio predicted the knee extensor moment ratio (R2 = 0.854, P<.001). At 5 months, the hip-to-knee extensor moment ratio predicted the knee extensor moment ratio (R2 = 0.584, P = .006). Conclusion Individuals used interlimb and intralimb compensations to reduce the knee extensor moment of the surgical limb at 3 months post ACLR. Similar reductions in the knee extensor moment at 5 months were accomplished with only intralimb compensations. J Orthop Sports Phys Ther 2018;48(9):713-718. Epub 12 Jun 2018. https://doi.org/10.2519/jospt.2018.7977.

Characterizing knee loading asymmetry in individuals following anterior cruciate ligament reconstruction using inertial sensors.

Limitations in the ability to identify knee extensor loading deficits during gait in individuals following anterior cruciate ligament reconstruction (ACLr) may underlie their persistence. A recent study suggested that shank angular velocity, directly output from inertial sensors, differed during gait between individuals post-ACLr and controls. However, it is not clear if this kinematic variable relates to knee moments calculated using joint kinematics and ground reaction forces. Heel rocker mechanics during loading response of gait, characterized by rapid shank rotation, require knee extensor control. Measures of shank angular velocity may be reflective of knee moments. This study investigated the relationship between shank angular velocity and knee extensor moment during gait in individuals (n=19) 96.7±16.8days post-ACLr. Gait was assessed concurrently using inertial sensors and a marker-based motion system with force platforms. Peak shank angular velocity and knee extensor moment were strongly correlated (r=0.75, p<0.001) and between limb ratios of angular velocity predicted between limb ratios of extensor moment (r(2)=0.57, p<0.001) in the absence of between limb differences in spatiotemporal gait parameters. The strength of these relationships indicate that shank kinematic data offer meaningful information regarding knee loading and provide a potential alternative to full motion analysis systems for identification of altered knee loading following ACLr.

Knee loading asymmetries during gait and running in early rehabilitation following anterior cruciate ligament reconstruction: A longitudinal study.

BACKGROUND: Normalization of gait is expected 8-12 weeks after anterior cruciate ligament reconstruction and is a criterion for progression to running. Long-term persistence of sagittal knee loading deficits suggests that early goals are not met. Magnitude and progression of deficits in gait during this time and their relationship to deficits in running are not known. METHODS: 12 individuals status-post reconstruction (5 males) underwent 3-dimensional motion analysis of gait after surgery: one (T1) and three (T2) months and at initiation of running (T3); and running T3. Repeated measures ANOVAs (limb × time) assessed differences in knee flexion, extensor moment impulse and negative work in gait; paired t-tests compared limbs during running; and Pearson's correlations determined associations between limb ratios (moment and work) in gait and running. FINDINGS: Less flexion (-4.4 (0.63) degrees; mean (SE)), 35% smaller extensor moment (-0.15 (0.006) Nm∗s/kg) and 47% less work (-0.03 (0.008) J/kg) were observed in the surgical knee during gait across time. Moment and work were 1.7 (-0.1 (0.03) Nm∗s/kg) and 1.6 times greater (-0.23 (0.047) J/kg) in non-surgical knee during running. Moment and work limb asymmetries correlated across time during gait (r=0.778-0.929, P<0.001) and to asymmetries during running. INTERPRETATION: Limb asymmetries in knee loading present one month after reconstruction persist 4 months post-reconstruction. Correlations between limb asymmetries during gait across time and to running suggest that early gait behaviors relate to longer-term loading. Greater attention should be placed on early gait training.

Predicting daily gait behaviors after anterior cruciate ligament surgery: A case study.

After surgical interventions such as anterior cruciate ligament reconstruction (ACLr), people exhibit altered gait mechanics due to joint impairments. Persistence of altered mechanics after resolution of impairments may be related to daily reinforcement of maladaptive behavior. Quantifying the contribution of such maladaptive motor strategies requires continuous monitoring of locomotor behaviors in the home setting. In this paper, we investigate an inertial sensor based approach to monitoring ambient activities. We evaluate the relative performance of our predictive algorithm on one control and one individual post-ACL reconstruction.