ABSTRACT
Irreversible sensorineural hearing loss is one of the most common side effects after cisplatin treatment. Prevention and reversal of hearing loss caused by cisplatin are of great importance for cancer patients, especially children. Oxidative stress is an important cause of hearing loss resulted from cisplatin, unfortunately, there is no drug yet available that can completely prevent and reverse the ototoxicity from cisplatin. Polydatin (PD) possesses excellent antioxidant and anti-inflammatory effects, however, its role in the cisplatin-induced hearing loss has not been investigated. Herein, we have explored the preventive and therapeutic effects of PD on cisplatin-induced hearing loss and the possible underlying mechanisms. In the in vivo setting with guinea pigs, we have demonstrated that PD can reduce the threshold shift of auditory brainstem response (ABR) caused by cisplatin, promote the nuclear translocation of Nuclear factor erythroid-2 related factor 2 (Nrf2), increase the expression of Nrf2 and heme oxygenase-1 (HO-1), and thus reduce the loss of outer hair cells (OHCs). PD can ameliorate cisplatin-induced hearing loss through activating the Nrf2/HO-1 signaling pathway. This study provides a potential strategy for preventing and improving hearing loss resulted from cisplatin treatment in clinics.
ABSTRACT
OBJECTIVES: Childhood obstructive sleep apnea (OSA) is underdiagnosed. The aim of this study was to assess the awareness level of OSA among parents in the general population of Guangdong province of South China. METHODS: This descriptive epidemiological study was conducted from July to November 2019 using an anonymous questionnaire that evaluated the knowledge of OSA-related symptoms and complications. Exclusion criteria included age under 18 years, refusal to fill out the questionnaire, and a linguistic barrier. RESULTS: A total of 1123 respondents participated in the survey. Among them, 530 (47.2%) respondents were aware of childhood OSA. The most common source of information about childhood OSA was the internet (49.9%). On multivariate analysis, the respondents obtained higher scores if they were mothers (B: -0.105, 95% confidence interval [CI]: -0.153,-0.057), lived in an urban area (B: -0.077, 95% CI: -0.125,-0.28), and knew about childhood OSA previously (B: -0.55, 95% CI:-0.598,-0.502). CONCLUSION: Parents demonstrated limited awareness of OSA complications. Innovative educational campaigns must be organized to inform medical practitioners and the general public about this disease and raise awareness about its complications. The effectiveness of the ongoing health education campaigns to increase awareness should be monitored by examining the temporal trends in public knowledge of childhood sleep apnea.
