Association between genetic polymorphisms of PTGS2 and glioma in a Chinese population.

Several previous studies indicated that genetic polymorphisms in inflammatory factor genes were associated with glioma risk. However, the relationship between the prostaglandin-endoperoxide synthase 2 (PTGS2) genetic polymorphism and glioma remains unclear in the Chinese population. We selected 199 histologically confirmed adult glioma patients and 199 cancer-free controls for the present study and analyzed the distribution of the PTGS2 genotypes and haplotypes. We found that the CC+CT genotype of rs5275 was common in the control group but not in the glioma group (P = 0.033). In addition, we found that the frequency of the C allele was higher in the control group than in the glioma group (P = 0.014). For rs6681231, although we found no significant difference between the 2 groups in genotype distribution, we found that the frequency of the C allele was lower in glioma patients than in control subjects (P = 0.044). We found no significant difference between these 2 groups in the rs689466 genotype and allele distributions. Haplotype analysis suggested that the frequency of the C-A-C haplotype was significantly lower in glioma patients than in control subjects [P = 0.028, odds ratio (OR) = 0.628, 95% confidence interval (CI) = 0.413-0.955]. However, the frequency of the T-A-G haplotype was higher in glioma patients than in control subjects (P = 0.036, OR = 1.418, 95%CI = 1.022-1.967). Therefore, polymorphisms in the PTGS2 gene may be associated with glioma susceptibility in the Chinese population.

A magnetic reconnection X-line extending more than 390 Earth radii in the solar wind.

Magnetic reconnection in a current sheet converts magnetic energy into particle energy, a process that is important in many laboratory, space and astrophysical contexts. It is not known at present whether reconnection is fundamentally a process that can occur over an extended region in space or whether it is patchy and unpredictable in nature. Frequent reports of small-scale flux ropes and flow channels associated with reconnection in the Earth's magnetosphere raise the possibility that reconnection is intrinsically patchy, with each reconnection X-line (the line along which oppositely directed magnetic field lines reconnect) extending at most a few Earth radii (R(E)), even though the associated current sheets span many tens or hundreds of R(E). Here we report three-spacecraft observations of accelerated flow associated with reconnection in a current sheet embedded in the solar wind flow, where the reconnection X-line extended at least 390R(E) (or 2.5 x 10(6) km). Observations of this and 27 similar events imply that reconnection is fundamentally a large-scale process. Patchy reconnection observed in the Earth's magnetosphere is therefore likely to be a geophysical effect associated with fluctuating boundary conditions, rather than a fundamental property of reconnection. Our observations also reveal, surprisingly, that reconnection can operate in a quasi-steady-state manner even when undriven by the external flow.

Tectonic implications of Mars crustal magnetism.

Mars currently has no global magnetic field of internal origin but must have had one in the past, when the crust acquired intense magnetization, presumably by cooling in the presence of an Earth-like magnetic field (thermoremanent magnetization). A new map of the magnetic field of Mars, compiled by using measurements acquired at an approximately 400-km mapping altitude by the Mars Global Surveyor spacecraft, is presented here. The increased spatial resolution and sensitivity of this map provide new insight into the origin and evolution of the Mars crust. Variations in the crustal magnetic field appear in association with major faults, some previously identified in imagery and topography (Cerberus Rupes and Valles Marineris). Two parallel great faults are identified in Terra Meridiani by offset magnetic field contours. They appear similar to transform faults that occur in oceanic crust on Earth, and support the notion that the Mars crust formed during an early era of plate tectonics.

In situ discovery of an electrostatic potential, trapping electrons and mediating fast reconnection in the Earth's magnetotail.

Anisotropic electron phase space distributions, f, measured by the Wind spacecraft in a rare crossing of a diffusion region in Earth's far magnetotail (60 Earth radii), are analyzed. We use the measured f to probe the electrostatic and magnetic geometry of the diffusion region. For the first time, the presence of a strong electrostatic potential (1 kV) within the ion diffusion region is revealed. This potential has far reaching implications for the reconnection process; it accounts for the observed acceleration of the unmagnetized ions out of the reconnection region and it causes all thermal electrons be trapped electrostatically. The trapped electron motion implies that the thermal part of the electron distributions are symmetric around v( parallel)=0: f(v( parallel),v( perpendicular)) approximately f(-v( parallel),v( perpendicular)). It follows that the field aligned currents in the diffusion region are limited and fast magnetic reconnection is mediated.

Terrestrial gamma-ray flashes observed up to 20 MeV.

Terrestrial gamma-ray flashes (TGFs) from Earth's upper atmosphere have been detected with the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) satellite. The gamma-ray spectra typically extend up to 10 to 20 megaelectron volts (MeV); a simple bremsstrahlung model suggests that most of the electrons that produce the gamma rays have energies on the order of 20 to 40 MeV. RHESSI detects 10 to 20 TGFs per month, corresponding to approximately 50 per day globally, perhaps many more if they are beamed. Both the frequency of occurrence and maximum photon energy are more than an order of magnitude higher than previously known for these events.

Evidence for electron acceleration up to approximately 300 keV in the magnetic reconnection diffusion region of earth's magnetotail.

We report direct measurements of high-energy particles in a rare crossing of the diffusion region in Earth's magnetotail by the Wind spacecraft. The fluxes of energetic electrons up to approximately 300 keV peak near the center of the diffusion region and decrease monotonically away from this region. The diffusion region electron flux spectrum obeys a power law with an index of -3.8 above approximately 2 keV, and the electron angular distribution displays strong field-aligned bidirectional anisotropy at energies below approximately 2 keV, becoming isotropic above approximately 6 keV. These observations indicate significant electron acceleration inside the diffusion region. Ions show no such energization.

In situ detection of collisionless reconnection in the Earth's magnetotail.

Magnetic reconnection is the process by which magnetic field lines of opposite polarity reconfigure to a lower-energy state, with the release of magnetic energy to the surroundings. Reconnection at the Earth's dayside magnetopause and in the magnetotail allows the solar wind into the magnetosphere. It begins in a small 'diffusion region', where a kink in the newly reconnected lines produces jets of plasma away from the region. Although plasma jets from reconnection have previously been reported, the physical processes that underlie jet formation have remained poorly understood because of the scarcity of in situ observations of the minuscule diffusion region. Theoretically, both resistive and collisionless processes can initiate reconnection, but which process dominates in the magnetosphere is still debated. Here we report the serendipitous encounter of the Wind spacecraft with an active reconnection diffusion region, in which are detected key processes predicted by models of collisionless reconnection. The data therefore demonstrate that collisionless reconnection occurs in the magnetotail.

Silicone lymphadenopathy. A case report and review of the literature.

A case of silicone lymphadenopathy secondary to silicone mammary implantation is reported. With the recent publicity regarding possible adverse effects of silicone, pathologists need to be aware of this rare complication of silicone implantation.

The hot plasma environment at jupiter: ulysses results.

Measurements of the hot plasma environment during the Ulysses flyby of Jupiter have revealed several new discoveries related to this large rotating astrophysical system. The Jovian magnetosphere was found by Ulysses to be very extended, with the day-side magnetopause located at approximately 105 Jupiter radii. The heavy ion (sulfur, oxygen, and sodium) population in the day-side magnetosphere increased sharply at approximately 86 Jupiter radii. This is somewhat more extended than the "inner" magnetosphere boundary region identified by the Voyager hot plasma measurements. In the day-side magnetosphere, the ion fluxes have the anisotropy direction expected for corotation with the planet, with the magnitude of the anisotropy increasing when the spacecraft becomes more immersed in the hot plasma sheet. The relative abundances of sulfur, oxygen, and sodium to helium decreased somewhat with decreasing radial distance from the planet on the day-side, which suggests that the abundances of the Jupiter-derived species are dependent on latitude. In the dusk-side, high-latitude region, intense fluxes of counter-streaming ions and electrons were discovered from the edge of the plasma sheet to the dusk-side magnetopause. These beams of electrons and ions were found to be very tightly aligned with the magnetic field and to be superimposed on a time- and space-variable isotropic hot plasma background. The currents carried by the measured hot plasma particles are typically approximately 1.6 x 10(-4) microamperes per square meter or approximately 8 x 10(5) amperes per squared Jupiter radius throughout the high-latitude magnetosphere volume. It is likely that the intense particle beams discovered at high Jovian latitudes produce auroras in the polar caps of the planet.

Evidence for chain molecules enriched in carbon, hydrogen, and oxygen in comet halley.

In situ measurements of the composition and spatial distribution of heavy thermal positive ions in the coma of comet Halley were made with the heavy-ion analyzer RPA2-PICCA aboard the Giotto spacecraft. Above 50 atomic mass units an ordered series of mass peaks centered at 61, 75, 91, and 105 atomic mass units were observed. Each peak appears to be composed of three or more closely spaced masses. The abundances decrease and the dissociation rates increase smoothly with increasing mass. These observations suggest the presence of chain molecules that are enriched in carbon, oxygen, and hydrogen, such as polyoxymethylene (polymerized formaldehyde), in comet Halley.