ABSTRACT
BACKGROUND AND STUDY AIMS: Delayed perforation is a rare complication of therapeutic colonoscopy, and it is severe and sometimes lethal. This paper reports on a new minimally invasive method for the treatment of delayed colonic perforation. PATIENTS AND METHODS: Three patients with delayed colonic perforation underwent the therapy, which involved three steps: (1) closure with endoclips and loop, (2) overtube placement, and (3) antibiotic wash through a nasobiliary tube. RESULTS: The procedure was successful in all three patients and no recurrence was observed during 5â-â41 months of follow-up. CONCLUSIONS: Although this study involved only a small number of patients and no control arm, the method involving an overtube appears to be a feasible and effective endoscopic treatment for delayed colonic perforation.
Subject(s)
Colonoscopy/methods , Intestinal Perforation/therapy , Therapeutic Irrigation , Adult , Aged , Anti-Infective Agents/administration & dosage , Colonoscopy/adverse effects , Colonoscopy/instrumentation , Dissection/adverse effects , Female , Humans , Intestinal Mucosa/surgery , Intestinal Perforation/etiology , Male , Metronidazole/administration & dosage , Middle Aged , Time FactorsABSTRACT
Human telomerase reverse transcriptase (hTERT) has been identiï¬ed as a major protein involved in aberrant cell proliferation, immortalization, metastasis and stemness maintenance in a majority of tumors, yet it has little or no expression in normal somatic cells. During the past few years, the development of hTERT-based therapies such as immunotherapy, suicide gene therapy and small-molecule interfering therapy have become critical and specific for eradicating all types of cancer. Here, current knowledge regarding hTERT and its involvement in various cancers and its role as a target of cancer therapies are reviewed. Additionally, hurdles to new cancer therapy development and new therapeutic opportunities are described, along with areas that require further investigation.
