Incidence and factors associated with dysphagia in intensive care unit patients 24 h after extubation.

BACKGROUND: Post-extubation dysphagia deserves attention because it places patients at risk following extubation, especially critically ill patients in intensive care unit. However, there are limited studies of post-extubation dysphagia in the early stages after extubation. AIMS: To investigate the incidence and factors associated with post-extubation dysphagia among patients in intensive care unit within 24 h of extubation. STUDY DESIGN: A prospective descriptive study was carried out with 173 adult patients in intensive care unit with tracheal extubation at a tertiary hospital in Guangzhou, China. The Gugging Swallowing Screen was used to evaluate the swallowing function of patients 1, 4 and 24 h after extubation. Demographic and clinical data were retrieved from medical records. RESULTS: The incidence of post-extubation dysphagia in patients within 1, 4 and 24 h after extubation was 86.71% (n = 150), 63.01% (n = 109) and 43.35% (n = 75), respectively. The risk factors included older age (OR = 1.057, 95%CI [1.039, 1.072], p < .001), cardiovascular disease (OR = 0.098, 95%CI [0.082, 0.127], p = .012), thyroid dysfunction (OR = 5.042, 95%CI [1.527, 13.684], p < .001), non-post-operative admission (OR = 3.186, 95%CI [1.142, 14.422], p = .036), mechanical ventilation duration >48 h (OR = 3.558, 95%CI [1.217, 10.385], p = .020), intubation duration >24 h (OR = 0.533, 95%CI [0.278, 0.898], p = .048) and intubation model size ≤7 (OR = 0.327, 95%CI [0.158, 0.788], p < .01). CONCLUSIONS: This study revealed a high incidence of post-extubation dysphagia in critical patients in the 24 h after extubation, with the incidence decreasing over time. Screening of early post-extubation dysphagia after extubation is needed, but the specific evaluation time point requires further investigation. Patients with older age, cerebrovascular disease, thyroid dysfunction, post-operative admission, longer mechanical ventilation time, thicker intubation models and longer intubation time have a higher risk of the occurrence of post-extubation dysphagia. RELEVANCE TO CLINICAL PRACTICE: The incidence of post-extubation dysphagia is very high in the early stage. Within 24 h after extubation, the patient's swallowing function should be actively evaluated, and the occurrence of aspiration should be vigilant. Patients with older age, cerebrovascular disease, thyroid dysfunction, post-operative admission, longer mechanical ventilation time, thicker intubation models and longer intubation time should receive more attention.

Parental self-efficacy and family quality of life in parents of children with autism spectrum disorder in China: The possible mediating role of social support.

OBJECTIVE: This study explored the related factors of FQOL in parents of children with ASD and examined whether social support mediates the relationship between parental self-efficacy and FQOL in parents of children with ASD. DESIGN AND METHODS: Using a cross-sectional design, a total of 260 parents of children with ASD were recruited from September 2019 to November 2020. They completed the Beach Center Family Quality of Life Scale, the Parenting Sense of Competence Scale, and the Social Support Rating Scale. RESULTS: Parental self-efficacy and social support explained approximately 49.5% of the variance in FQOL. After controlling for the confounding influence of parents' education level, parental self-efficacy had a direct effect on FQOL (ß = 0.292, SE = 0.108, P < 0.01) and an indirect effect on FQOL (ß = 0.165, SE = 0.069, P < 0.01). Effects were mediated through social support, with partial mediating effects accounting for 36.11% of the total effect. CONCLUSIONS: Both parental self-efficacy and social support are critical to promoting FQOL, and a partial mediating effect of social support was established. PRACTICAL IMPLICATIONS: Interventions for families with children with ASD should focus on enhancing parental self-efficacy, followed by a perceived social support and FQOL prompt.

Effects of Animal-Assisted Therapy on Hospitalized Children and Teenagers: A Systematic Review and Meta-Analysis.

PROBLEM: Psychological and symptom disturbances seriously affect hospitalized children's subjective experiences of hospitalization and their prognosis. We systematically reviewed the effects of animal-assisted therapy (AAT) on pain, anxiety, depression, stress, blood pressure (BP), and heart rate (HR) in hospitalized children and teenagers. ELIGIBILITY CRITERIA: A systematic review and meta-analysis were conducted using the English-language electronic databases PubMed, EMBASE, Web of Science, the Cochrane Library, Clinical Trials, Science Direct, EBSCOhost, Open Grey and Google Scholar, and the Chinese databases CNKI, Sinomed, Vip, and WanFang. These databases were searched through July 15, 2020. SAMPLE: Eight studies, including four randomized controlled trials (RCTs) and four quasi-experimental studies were included, with a total of 348 participants. RESULTS: Hospitalized children and teenagers with AAT had less pain (standardized mean difference = -0.49; 95% confidence interval [CI], -0.77 to -0.22; P < 0.001), lower systolic blood pressure (mean difference [MD] = -4.85; 95% CI, -9.50 to -0.21; P= 0.04), higher diastolic blood pressure (MD = 4.95; 95% CI, 1.90 to 8.00; P = 0.001) than controls, while there was no significant difference in depression, anxiety, stress, or HR. CONCLUSION: As an adjuvant to traditional treatment, AAT was beneficial for controlling pain and BP in hospitalized children and teenagers. IMPLICATION: AAT may be an effective strategy for relieving pain and controlling BP in hospitalized children and teenagers, especially those with cancer. High-quality RCTs conducted or supported by nurses on the effects of AAT are needed.

Characteristics of diffusion tensor imaging of central nervous system in children with tourette's disease.

To investigate the characteristics of diffusion tensor imaging (DTI) of the central nervous system in children with Tourette syndrome (TS).Fifteen children with TS (TS group) and 15 normal children (control group) were studied, and all of them underwent DTI. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) parameters were calculated using the DTIStudio software. The region of interest was delineated manually. The ADC and FA values of the bilateral caudate nucleus, bilateral globus pallidus, bilateral putamen, bilateral thalamus, and bilateral frontal lobe white matter were measured using the region of interest editor software. The differences of FA values and ADC values between the same brain areas were compared. The associations between ADC, FA values and Yale Global Tic Severity Scale (YGTSS) scores were evaluated by Pearson correlation analyses.The FA values of left globus pallidus and left thalamus were significantly lower in the TS group than in the control group (P < .05), while the ADC values of the right caudate nucleus and bilateral thalamus were significantly higher in the TS group than in the control group (P < .05). The decrease in FA in the left thalamus significantly correlated with the YGTSS score (r = 0.692; P < .05). No correlation was found between FA and ADC values in other brain regions and the YGTSS score (P > .05).After the DTI analyses, abnormalities were found in the left globus pallidus, right caudate nucleus, and bilateral thalamus in children with TS. Especially the changes in the left thalamus structure was crucial in the pathophysiological clock of TS.

Comparison and Fusion of Deep Learning and Radiomics Features of Ground-Glass Nodules to Predict the Invasiveness Risk of Stage-I Lung Adenocarcinomas in CT Scan.

For stage-I lung adenocarcinoma, the 5-years disease-free survival (DFS) rates of non-invasive adenocarcinoma (non-IA) is different with invasive adenocarcinoma (IA). This study aims to develop CT image based artificial intelligence (AI) schemes to classify between non-IA and IA nodules, and incorporate deep learning (DL) and radiomics features to improve the classification performance. We collect 373 surgical pathological confirmed ground-glass nodules (GGNs) from 323 patients in two centers. It involves 205 non-IA (including 107 adenocarcinoma in situ and 98 minimally invasive adenocarcinoma), and 168 IA. We first propose a recurrent residual convolutional neural network based on U-Net to segment the GGNs. Then, we build two schemes to classify between non-IA and IA namely, DL scheme and radiomics scheme, respectively. Third, to improve the classification performance, we fuse the prediction scores of two schemes by applying an information fusion method. Finally, we conduct an observer study to compare our scheme performance with two radiologists by testing on an independent dataset. Comparing with DL scheme and radiomics scheme (the area under a receiver operating characteristic curve (AUC): 0.83 ± 0.05, 0.87 ± 0.04), our new fusion scheme (AUC: 0.90 ± 0.03) significant improves the risk classification performance (p < 0.05). In a comparison with two radiologists, our new model yields higher accuracy of 80.3%. The kappa value for inter-radiologist agreement is 0.6. It demonstrates that applying AI method is an effective way to improve the invasiveness risk prediction performance of GGNs. In future, fusion of DL and radiomics features may have a potential to handle the classification task with limited dataset in medical imaging.

Preoperative evaluation of neurovascular relationship in trigeminal neuralgia by three-dimensional fast low angle shot (3D-FLASH) and three-dimensional constructive interference in steady-state (3D-CISS) MRI sequence.

OBJECTIVE: The purpose of the study was to evaluate the value of high-resolution three-dimensional fast low angle shot (3D-FLASH) and three-dimensional constructive interference in steady-state (3D-CISS) MRI sequence solely or the combination of both in the visualization of neurovascular relationship in patients with trigeminal neuralgia (TN). METHODS: 65 patients with unilateral TN underwent 3D-FLASH and 3D-CISS imaging were retrospectively studied. Neurovascular relationship at the intracisternal segment of trigeminal nerve was reviewed by two experienced neuroradiologist, who was blinded to the clinical details. The imaging results were compared with the operative findings in all patients. RESULTS: The accuracy and positive rates of the 3D-FLASH + CISS imaging (98.46, 92.31%) in judging the symptomatic side according to the presence of vascular contacts were higher than those of 3D-CISS (90.77%, 84.62) or 3D-FLASH (89.23, 83.08%) sequence. In addition, the statistical analysis showed the sensitivity and accuracy of 3D-FLASH + CISS imaging was higher than that of 3D-FLASH (p < 0.05). The 3D-FLASH + CISS imaging was more accurate in determining the type of offending vessel than 3D-CISS or 3D-FLASH imaging. CONCLUSION: The retrospective study demonstrates that the combination of 3D-FLASH with 3D-CISS sequence well delineates the relationship between intracisternal segment of trigeminal nerve and adjacent vessels in terms of increased positive rates and accuracy. Advances in knowledge: The study firstly dealt with the combination of 3D-CISS and 3D-FLASH imaging in TN.

Diagnosis of Struma ovarii with medical imaging.

OBJECTIVE: To analyze the imaging features of Struma ovarii (SO), and to correlate the imaging results with the pathological findings so as to enhance the knowledge of the imaging diagnostics of this disease. METHODS: The clinical records, CT and MRI features of twelve patients with pathologically proved SO were retrospectively analyzed. Imaging features were compared with pathological results. RESULTS: Most tumors (n = 11, 91.7%) were unilateral. In CT and MRI images, the lesions presented as defined irregularly shaped masses, showing mainly cystic (n = 6, 50%) or cystic (n = 6, 50%). The cystic portions presented as well defined, multiple, various size, and a whole cyst wall with smooth inner wall. Eight cases of tumors (66.7%) showed a high attenuation lesion in the cyst portion of the mass on CT precontrast scans, in which two cases showed high signal on T1WI and low signal on T2WI. The solid portions, which distributed in the cyst showed irregular tissue density. After contrast administration, the cystic portions showed no enhancement, the solid portions marked enhancement, and the cyst wall demonstrated no, moderate, or marked enhancement. Eight cases of tumors (66.7%) showed stippled calcification in the cyst wall. Four cases of tumors (33.3%) accompany a great of abdominal dropsy and pleural fluid. CONCLUSIONS: In general, SO appeared as a smooth marginated multicystic mass with a high attenuation lesion on precontrast scans on CT scans, and signal intensities on T1-weighted images were partly intermediate to high, or high, and those on T2-weighted images were low. The CT and MRI characteristic findings of SO might be of great value for the diagnosis.