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Bioorg Med Chem Lett ; 19(4): 1264-6, 2009 Feb 15.
Article in English | MEDLINE | ID: mdl-19167219

ABSTRACT

Two types of new chrysin derivatives were prepared by coupling NO donors of alkyl nitrate and furazan derivatives and were fully characterized by (1)H NMR and other techniques. These compounds were tested in human umbilical vein endothelial cells (HUVECs-12) and all the compounds exhibited cell proliferation. Notable effects of promoting angiogenesis were observed for all the modified compounds using chick chorioallantoic membrane (CAM) assay.


Subject(s)
Angiogenesis Inducing Agents/chemical synthesis , Chorioallantoic Membrane/blood supply , Endothelial Cells/drug effects , Flavonoids/chemical synthesis , Flavonoids/pharmacology , Nitrates/chemical synthesis , Nitrates/pharmacology , Oxadiazoles/chemical synthesis , Oxadiazoles/pharmacology , Angiogenesis Inducing Agents/pharmacology , Animals , Cell Proliferation/drug effects , Chick Embryo , Chorioallantoic Membrane/metabolism , Flavonoids/chemistry , Humans , Molecular Structure , Nitrates/chemistry , Nitric Oxide Donors/chemistry , Nitric Oxide Donors/metabolism , Oxadiazoles/chemistry , Umbilical Veins/cytology
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