1.
Bioorg Med Chem Lett
; 22(21): 6694-9, 2012 Nov 01.
Article
in English
| MEDLINE
| ID: mdl-23021991
ABSTRACT
The discovery and optimisation of a series of zwitterionic CCR3 antagonists is described. Optimisation of the structure led to AZ12436092, a compound with excellent selectivity over activity at hERG and outstanding pharmacokinetics in preclinical species.