Abandono de tratamiento antirretroviral en pacientes femeninas en edad reproductiva con diagnóstico de virus de inmunodeficiencia humana VIH/ síndrome de inmunodeficiencia adquirida-SIDA- que asisten a la clínica de enfermedades infecciosas del Hospital Roosevelt / Abandonment of antiretroviral treatment in female patients of reproductive age diagnosed with HIV human immunodeficiency virus / acquired immunodeficiency syndrome-AIDS attending the clinic of infectious diseases at Roosevelt Hospital

La presente investigación tuvo como objetivo estudiar el abandono de tratamiento antirretroviral (ARV) en pacientes femeninas en edad reproductiva, consistió en determinar el porcentaje y las causas de abandono de dicho tratamiento en pacientes que asistieron a la Clínica de Enfermedades Infecciosas del Departamento de Medicina Interna del Hospital Roosevelt, durante el período de enero 2005 a diciembre 2009. La investigación fue de tipo descriptivo-retrospectivo, mediante revisión sistemática de 1,000 registros médicos de pacientes a estudio que evidenciaron el inicio de tratamiento antirretroviral y el abandono del mismo por un mínimo de dos meses consecutivos...

Dermatitis Atópica y Oxigenación Hiperbárica

Se analizó el caso de una paciente de 35 años, del sexo femenino con el diagnóstico de dermatitis atópica del adulto de muy mal manejo y de curso persistente lo que motivó el ingreso en varias ocasiones en el servicio de dermatología del Hospital Provincial Clínico Quirúrgico de Sancti-Spíritus, recibiendo como terapia complementaria la Oxigenación Hiperbárica, evolucionando con resolución de su enfermedad.

Empleo del Interferón alfa 2b recombinente humano en pacientes con melanoma de alto riesgo

Se realizó un estudio descriptivo que incluyó a los pacientes con el diagnóstico de melanoma de riesgo que se le realizó cirugía con confirmación histologica, la muestra que se seleccionó para el estudio con estrictos criterios estuvo integrada por 13 pacientes. Se presentaron efectos adversos en 11 pacientes siendo los más frecuentes la fiebre, los escalofríos y la cefalea, de los 13 pacientes 12 están vivos y 9 con la enfermedad controlada. Seis pacientes abandonaron el estudio de forma voluntaria por no sentirse satisfechos con el tratamiento.[AU]

Intervención educativa sobre infecciones de trasmisión sexual en adolescente, ESBU Victor Valle Ballester

Se realizó un trabajo referente a la educación sexual de los jóvenes de la ESBU Victor Valle Ballester de Sancti Spiritus dirigida a identificar los conocimientos sobre las ITS. Se relacionaron las posibles causas y efectos de las enfermedades de trasmisión sexual. Se analizaron las características propias de los adolescentes y su comportamiento arriesgado a exponerse a estas enfermedades. Con la intervención educativa se logró elevarel nivel de conocimiento asi como la percepción de riesgo de nuestros estudiantes.[AU]

Epstein-Barr virus-associated gastric carcinoma in Lima, Peru.

We examined 254 gastric carcinomas (GCs) diagnosed in four hospitals in Lima, Peru, and its suburban area during the period between 1994-2001. Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) was identified by the in situ hybridization (ISH) technique to detect EBV-encoded small RNA (EBER) in gastric tissue. EBVaGCs, where EBER ISH staining was observed in all carcinoma cells, accounted for 3.9% (10/254) of gastric adenocarcinomas, the lowest frequency ever reported in Latin American countries. EBVaGC incidence rates in Peru, which we estimated on the basis of the present study and cancer incidence in Lima, were 0.8 per 100,000 among men and 0.5 per 100,000 among women. These estimates are much lower than those reported in our previous studies in Colombia (4.1 and 1.4 per 100,000 among men and women, respectively), a neighboring country, and in Japan (6.4 and 1.1 per 100,000 among men among women, respectively). Interestingly, EBVaGC in Peru showed no evident male predominance, as opposed to the findings reported in a majority of studies. Other clinicopathological features of EBVaGC in Peru were similar to those found in literature: EBVaGC showed no age dependence, a predominance in the non-antrum part of the stomach, and high frequencies in histological subtypes of moderately differentiated tubular adenocarcinoma and solid poorly differentiated adenocarcinoma. There was a case of well-differentiated adenocarcinoma showing a partial EBER-1-positive staining. In this carcinoma, the tumor in the body (middle third of the stomach) was EBER-1 positive but the tumor in the stomach antrum showed no noticeable EBER-1 ISH staining. We suspect this was a case of synchronous double carcinomas. Further studies are needed to identify the cause of the low frequency and lack of male predominance of EBVaGC in Peru.

In vivo aggregation of the HET-s prion protein of the fungus Podospora anserina.

We have proposed that the [Het-s] infectious cytoplasmic element of the filamentous fungus Podospora anserina is the prion form of the HET-s protein. The HET-s protein is involved in a cellular recognition phenomenon characteristic of filamentous fungi and known as heterokaryon incompatibility. Under the prion form, the HET-s protein causes a cell death reaction when co-expressed with the HET-S protein, from which it differs by only 13 amino acid residues. We show here that the HET-s protein can exist as two alternative states, a soluble and an aggregated form in vivo. As shown for the yeast prions, transition to the infectious prion form leads to aggregation of a HET-s--green fluorescent protein (GFP) fusion protein. The HET-s protein is aggregated in vivo when highly expressed. However, we could not demonstrate HET-s aggregation at wild-type expression levels, which could indicate that only a small fraction of the HET-s protein is in its aggregated form in vivo in wild-type [Het-s] strains. The antagonistic HET-S form is soluble even at high expression level. A double amino acid substitution in HET-s (D23A P33H), which abolishes prion infectivity, suppresses in vivo aggregation of the GFP fusion. Together, these results further support the model that the [Het-s] element corresponds to an abnormal self-perpetuating aggregated form of the HET-s protein.

[Importance of arteriography in the localization of insulinomas. Report of 2 new clinical cases]. / Importancia de la arteriografía en la localización de los insulinomas. Aportación de dos nuevos casos clínicos.

Two new clinical cases of insulinomas are reported, confirming the immense value of selective arteriography of the celiac trunk and upper mesenteric artery in localizing the tumor.