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3.
J Endovasc Ther ; 30(6): 867-876, 2023 12.
Article in English | MEDLINE | ID: mdl-35735201

ABSTRACT

PURPOSE: The widespread adoption of endovascular aneurysm repair (EVAR) as preferred treatment modality for abdominal aortic aneurysm (AAA) has enlarged the number of patients needing open surgical conversion (OSC). The relationship between adherence to Instructions For Use (IFU) and EVAR long-term outcomes remains controversial. The aim of this study is to compare preoperative differences and postoperative outcomes between EVAR patients not adjusted to IFU and adjusted to IFU who underwent OSC. METHODS: This multicenter retrospective study reviewed 33 explanted EVARs between January 2003 and December 2019 at 14 Vascular Units. Patients were included if OSC occurred >30 days after implantation and excluded if explantation was performed to treat an endograft infection, aortic dissection, or traumatic transections. Variables analyzed included baseline characteristics, adherence to IFU, implant and explant procedural details, secondary reinterventions, and postoperative outcomes. RESULTS: Fifteen explanted patients (15/33, 45.5%) were identified not accomplished to IFU (out-IFU) at initial EVAR vs 18 explanted patients adjusted (in-IFU). During follow-up, a mean of 1.73±1.2 secondary reinterventions were performed, with more type I endoleaks treated in the subgroup out-IFU: 16.7% vs 6.3% in-IFU patients and more type III endoleaks (8.3% vs 0%). Patients out-IFU had shorter mean interval from implant to explant: 47.60±28.8 months vs 71.17±48. Type II endoleak was the most frequent indication for explantation. Low-flow endoleaks (types II, IV, V) account for 44% of indications for OSC in subgroup of patients in-IFU, compared with 13.3% in patients out-IFU and high-flow endoleaks (types I and III) were the main indication for patients out-IFU (33.3% vs 16.7% in-IFU). Total endograft explantation was performed in 57.5% of cases (19/33) and more suprarenal clamping was required in the subgroup out-IFU. Overall, 30-day mortality rate was 12.1% (4/33): 20% for patients out-IFU and 5.6% in-IFU. CONCLUSIONS: In our experience, type II endoleak is the most common indication for conversion and differences have been found between patients treated outside IFU with explantation taking place earlier during follow-up, mainly due to high-flow endoleaks and with higher mortality in comparison with patients adjusted to IFU. Ongoing research is required to delve into these differences.


Subject(s)
Aortic Aneurysm, Abdominal , Blood Vessel Prosthesis Implantation , Endovascular Procedures , Humans , Endoleak/etiology , Endoleak/surgery , Aortic Aneurysm, Abdominal/diagnostic imaging , Aortic Aneurysm, Abdominal/surgery , Blood Vessel Prosthesis Implantation/adverse effects , Endovascular Aneurysm Repair , Endovascular Procedures/adverse effects , Retrospective Studies , Treatment Outcome , Risk Factors
5.
Ann Vasc Surg ; 69: 449.e11-449.e16, 2020 Nov.
Article in English | MEDLINE | ID: mdl-32502671

ABSTRACT

BACKGROUND: Structural heart defects, secondary to congenital malformations, have been commonly repaired by open cardiac surgery. Endovascular technology enables these repairs to be performed with fewer complications and better recovery. However, endovascular therapy can be associated with major complications as device dislocation or embolization. We present the case of migration of an Amplatzer occluder device into the abdominal aorta and its surgical retrieval. CLINICAL CASE: A 10-year-old child with ostium secundum-type interatrial communication underwent endovascular repair in our center. Cardiologists sorted out the atrial communication by endovascular deployment of an Amplatzer device. The 24-h ultrasound control study showed the loss of the occluder. An angio-CT scan showed the migration of the Amplatzer into the juxtarenal abdominal aorta. Initially, an endovascular rescue was attempted but was not effective. Our vascular team performed a median laparotomy, control of the abdominal aorta proximal to the renal arteries, and control of the renal arteries and the infrarenal aorta. We performed a transverse arteriotomy, and the material was removed. Subsequently, the arteriotomy was closed directly without any patch. Postoperative evolution was uneventful. COMMENTS: Most of the migrations and embolizations of the devices to close interatrial communications remain intracardiac. Although embolization of the abdominal aorta is only reported sporadically, it could cause a major vascular complication. Percutaneous retrieval of the device is currently recommended, with conventional surgery being the efficient treatment in case of endovascular failure or severe damage to the aorta.


Subject(s)
Aorta, Abdominal/surgery , Cardiac Catheterization/instrumentation , Device Removal , Foreign-Body Migration/surgery , Heart Septal Defects, Atrial/therapy , Septal Occluder Device , Aorta, Abdominal/diagnostic imaging , Cardiac Catheterization/adverse effects , Child , Foreign-Body Migration/diagnostic imaging , Foreign-Body Migration/etiology , Heart Septal Defects, Atrial/diagnostic imaging , Humans , Treatment Outcome
6.
Ann Vasc Surg ; 67: 306-315, 2020 Aug.
Article in English | MEDLINE | ID: mdl-32173472

ABSTRACT

BACKGROUND: Endovascular techniques have become an essential tool for treatment of thoracic aortic pathology. The objective of this study was to analyze indications and results of thoracic endovascular aortic repair (TEVAR) in vascular surgery units, through a retrospective and multicentric national registry called Regis-TEVAR. METHODS: From 2012 to 2016, a total of 287 patients from 11 vascular surgery units, treated urgently and electively, were recruited consecutively. The primary variables analyzed are mortality, survival, and reintervention rate. The following indications for TEVAR were also analyzed: aortic dissections, thoracic aneurysms, traumatisms, and intramural hematomas or penetrating ulcers, as well as results and postoperative complications in accordance with each indication. RESULTS: Of the 287 TEVAR performed (239 men, mean age 64.1 ± 14.1 years), 155 were because of aortic aneurysm (54%), 90 because of type B aortic dissection (31.4%), 36 because of traumatic aortic rupture (12.5%), and 6 because of penetrating ulcers or intramural hematomas (2.1%). Overall mortality at 30 days was 11.5% (18.5% in urgent and 5.3% in elective), being higher in dissections (13.3%). The median actuarial survival was 73% at 4 years. The stroke rate was 3.1%, and the rate of spinal cord ischemia was 4.9%. Aortic reoperations were necessary in 23 patients (8.1%). CONCLUSIONS: This registry provides complete and reliable information on real clinical practice of TEVAR in Spain, with results similar to international series of open surgery. In accordance with these data, TEVAR can be performed with acceptable morbidity and mortality and with low rates of postoperative complications.


Subject(s)
Aorta, Thoracic/surgery , Aortic Diseases/surgery , Blood Vessel Prosthesis Implantation , Endovascular Procedures , Aged , Aorta, Thoracic/diagnostic imaging , Aortic Diseases/diagnostic imaging , Aortic Diseases/mortality , Blood Vessel Prosthesis Implantation/adverse effects , Blood Vessel Prosthesis Implantation/instrumentation , Blood Vessel Prosthesis Implantation/mortality , Endovascular Procedures/adverse effects , Endovascular Procedures/instrumentation , Endovascular Procedures/mortality , Female , Humans , Male , Middle Aged , Postoperative Complications/mortality , Postoperative Complications/surgery , Registries , Reoperation , Retrospective Studies , Risk Factors , Spain , Time Factors , Treatment Outcome
10.
Foot Ankle Surg ; 24(1): 60-64, 2018 Feb.
Article in English | MEDLINE | ID: mdl-29413776

ABSTRACT

BACKGROUND: The aim of this cohort study was to assess the inter-observer agreement of three diabetic foot classification systems: the Wagner, the University of Texas and the PEDIS. METHODS: We included 250 consecutive patients diagnosed of diabetic foot syndrome in 2009-2013. Wound scores were recorded at admission and a reevaluation was performed simultaneously or 24h later by a different evaluator. Demographical, laboratory data and associated risk factors were obtained from the patients' medical records. RESULTS: The Kappa coefficient showed a moderate inter-observer agreement between the first evaluation and the reevaluation for Wagner scale (Kappa=0.55; 95% CI: 0.507-0.593), University of Texas scale (Kappa=0.513; 95% CI: 0.463-0.563) and for PEDIS scale (Kappa=0.574; 95% CI: 0.522-0.626). CONCLUSIONS: This moderate agreement shows that these scales should not be used alone for management decisions regarding diabetic foot syndrome and should, therefore, be integrated with other clinical data to ensure an adequate handover.


Subject(s)
Diabetic Foot/classification , Severity of Illness Index , Aged , Amputation, Surgical , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 2/complications , Diabetic Foot/diagnosis , Diabetic Foot/etiology , Diabetic Foot/surgery , Female , Humans , Male , Middle Aged , Observer Variation , Prospective Studies , Wounds and Injuries/classification
11.
Enferm. infecc. microbiol. clín. (Ed. impr.) ; 34(8): 477-483, oct. 2016. ilus, tab, graf
Article in Spanish | IBECS | ID: ibc-156250

ABSTRACT

INTRODUCCIÓN: El objetivo principal del estudio ha sido valorar si la penetración de antibióticos se ve influenciada por la perfusión tisular disminuida en pacientes con isquemia de miembros, reduciendo la concentración alcanzada en tejidos por debajo de los puntos de corte (breakpoints) de la concentración mínima inhibitoria (CMI) de los antimicrobianos utilizados para diferentes patógenos. MÉTODOS: Estudio prospectivo. Se incluyeron candidatos a amputación mayor con isquemia crítica de miembro inferior e infección en tratamiento antibiótico. Se determinaron 3 niveles de perfusión en el miembro inferior, midiendo la presión transcutánea de oxígeno (TcPO2). Se extrajo una muestra de sangre de vía central así como biopsias de piel, músculo y hueso de cada uno de los niveles de perfusión. Se determinó la concentración del antibiótico mediante HPLC. RESULTADOS: El número total de casos es de 61 (46 pacientes): 6 clindamicina, 9 vancomicina, 8 linezolid, 18 levofloxacino, 9 ceftazidima y 11 meropenem. Se encuentran diferencias estadísticamente significativas entre todos los niveles de TcPO2 (ANOVA, p = 0,000). La concentración en piel de vancomicina, levofloxacino y ceftazidima depende del nivel de perfusión. Vancomicina y levofloxacino difunden peor en hueso que en el resto de tejidos. La concentración de ceftazidima no supera el punto de corte de Pseudomonas aeruginosa en tejidos isquémicos. CONCLUSIONES: Linezolid y meropenem difunden en todos los tejidos independientemente de la perfusión, alcanzando concentraciones superiores a la CMI de los microrganismos diana, asegurando su efectividad en tejidos isquémicos


INTRODUCTION: The aim of the study was to assess whether the penetration of antibiotics is affected by decreased tissue perfusion in patients with limb ischaemia, thus reducing its concentration in tissues below the minimum inhibitory concentration (MIC) breakpoints of antibiotics for different microorganisms. METHODS: rospective study. Candidates for major amputation with critical lower limb ischaemia and an infection on antibiotic treatment, were included. Three levels of perfusion in the lower limb were determined by measuring the transcutaneous oxygen pressure (TcPO2). A central line blood specimen, as well as biopsies of the skin, muscle, and bone, were taken at each perfusion level. The antibiotic concentration was determined using HPLC. RESULTS: The total number of cases was 61 (46 patients): 6 clindamycin, 9 vancomycin, 8 linezolid, 18 levofloxacin, 9 ceftazidime, and 11 meropenem. Statistically significant differences were found in TcPO2 at all levels (ANOVA, P=.000). The vancomycin, levofloxacin and ceftazidime skin concentration depends on perfusion. Vancomycin and levofloxacin diffusion in bone is worse than in other tissues. Ceftazidime concentration does not exceed the MIC breakpoint of Pseudomonas aeruginosa in ischaemic tissues. CONCLUSIONS: Meropenem and linezolid diffuse in all tissues, regardless of perfusion, reaching concentrations above the MIC of the target microorganisms, ensuring its effectiveness in ischaemic tissues


Subject(s)
Humans , Ischemia/drug therapy , Peripheral Vascular Diseases/drug therapy , Anti-Bacterial Agents/pharmacokinetics , Prospective Studies , Microbial Sensitivity Tests/methods
12.
Cir. Esp. (Ed. impr.) ; 94(3): 144-150, mar. 2016. tab, ilus
Article in Spanish | IBECS | ID: ibc-150084

ABSTRACT

INTRODUCCIÓN: Tradicionalmente la insuficiencia de safena anterior se trataba mediante crosectomía y resección de los paquetes varicosos. El objetivo del trabajo es mostrar la seguridad y eficacia de una nueva estrategia terapéutica en las varices dependientes de la vena safena magna accesoria anterior. MÉTODOS: Estudio prospectivo no ramdomizado que incluyó 65 pacientes con varices dependientes de la safena anterior con safena interna anterógrada. La modificación en la técnica consiste en hacer solamente flebectomía de los paquetes varicosos, sin ligar el cayado de la safena. Se realizó un estudio hemodinámico venoso preoperatorio, al mes y al año, y para la valoración clínica se utilizó la escala de Fligelstone. RESULTADOS: Clasificación clínica basal CEAP: C2 58%, C3 26% y C4-6 15%. Complicaciones: 3 hematomas, 7 casos de trombosis parciales asintomáticas de safena anterior. Se observó una reducción del diámetro medio inicial de safena anterior de 6,4 mm a 3,4 mm al año (p < 0,001). A los doce meses mantenían un flujo anterógrado el 82% de los casos. Hubo una recidiva de varices visibles en el 8% de los casos. Todos los pacientes han reflejado una mejoría clínica en la escala de Fligelstone. El diámetro de safena anterior mayor de 7,5 mm y la obesidad se identifican como predictores de un peor resultado clínico y hemodinámico. CONCLUSIONES: La modificación de la estrategia quirúrgica sobre las varices dependientes de la safena anterior presenta un resultado clínico favorable al año de la intervención


INTRODUCTION: Traditionally, anterior accessory great saphenous vein insufficiency was managed by crossectomy and resection of varicose veins. The aim of this paper is to show the safety and efficacy of a new therapeutic strategy for anterior accessory great saphenous varicose veins. METHODS: This non-randomised prospective study included 65 patients with varicose veins from the anterior accessory great saphenous vein. The novelty of the technique is to avoid the great saphenous vein crossectomy and perform just flebectomy of the visible veins. Venous duplex studies were performed preoperatively, a month and a year postoperatively. The clinical assessment was done by the Fligelstone scale. RESULTS: The baseline CEAP clinical classification was: 58% C2, 26% C3 and 15% C4-6. The new strategy was applied to all cases. Complications: 3 haematomas, 7 cases of asymptomatic partial anterior saphenous thrombosis. Reduction of the initial average diameter was from 6.4 mm anterior saphenous to 3.4 mm by one year (p < 0.001). At twelve months a forward flow is maintained in 82% of cases. Recurrence of varicose veins was 8%. All patients improved their clinical status based on the Fligelstone scale. Cases with saphenous diameter bigger than 7.5 mm and obesity were identified as predictors of worse clinical and hemodynamic outcome. CONCLUSIONS: This modified surgical strategy for anterior saphenous varicose veins results in better clinical outcomes at one year postoperatively


Subject(s)
Humans , Male , Female , Varicose Veins/surgery , Saphenous Vein/surgery , Hemodynamics/physiology , Hematoma/complications , Thrombosis/complications , Venous Insufficiency/complications , Venous Insufficiency/surgery , Evaluation of Results of Therapeutic Interventions , Efficacy/methods , Efficacy/standards , Treatment Outcome , Evaluation of the Efficacy-Effectiveness of Interventions , Prospective Studies , Varicose Veins/complications , Varicose Veins/physiopathology
13.
Cir Esp ; 94(3): 144-50, 2016 Mar.
Article in English, Spanish | MEDLINE | ID: mdl-26791174

ABSTRACT

INTRODUCTION: Traditionally, anterior accessory great saphenous vein insufficiency was managed by crossectomy and resection of varicose veins. The aim of this paper is to show the safety and efficacy of a new therapeutic strategy for anterior accessory great saphenous varicose veins. METHODS: This non-randomised prospective study included 65 patients with varicose veins from the anterior accessory great saphenous vein. The novelty of the technique is to avoid the great saphenous vein crossectomy and perform just flebectomy of the visible veins. Venous duplex studies were performed preoperatively, a month and a year postoperatively. The clinical assessment was done by the Fligelstone scale. RESULTS: The baseline CEAP clinical classification was: 58% C2, 26% C3 and 15% C4-6. The new strategy was applied to all cases. COMPLICATIONS: 3 haematomas, 7 cases of asymptomatic partial anterior saphenous thrombosis. Reduction of the initial average diameter was from 6.4 mm anterior saphenous to 3.4 mm by one year (p <0.001). At twelve months a forward flow is maintained in 82% of cases. Recurrence of varicose veins was 8%. All patients improved their clinical status based on the Fligelstone scale. Cases with saphenous diameter bigger than 7.5 mm and obesity were identified as predictors of worse clinical and hemodynamic outcome. CONCLUSIONS: This modified surgical strategy for anterior saphenous varicose veins results in better clinical outcomes at one year postoperatively.


Subject(s)
Saphenous Vein/surgery , Varicose Veins/surgery , Hemodynamics , Humans , Prospective Studies , Recurrence
14.
J Diabetes Complications ; 30(2): 329-34, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26644145

ABSTRACT

AIMS: To establish if the microbiology and the TEXAS, PEDIS and Wagner wound classifications of the diabetic foot syndrome (DFS) predict amputation. METHODS: Prospective cohort study of 250 patients with DFS from 2009 to 2013. Tissue samples for culture were obtained and wound classification scores were recorded at admission. RESULTS: Infection was monomicrobial in 131 patients (52%). Staphylococcus aureus was the most frequent pathogen (76 patients, 30%); being methicillin-resistant S. aureus in 26% (20/76) Escherichia coli and Enterobacter faecalis were 2nd and 3rd most frequent pathogens. Two hundred nine patients (85%) needed amputation being major in 25 patients (10%). The three wound scales associated minor amputation but did not predict this outcome. Predictors of minor amputation in the multivariate analysis were the presence of osteomyelitis, the location of the wound in the forefoot and of major amputation elevated C reactive proteine (CRP) levels. A low ankle-brachial index (ABI) predicted major amputation in the follow-up. Overall, 74% of gram-positives were sensitive to quinolones and 98% to vancomycin and 90% of gram-negatives to cefotaxime and 95% to carbapenems. CONCLUSIONS: The presence of osteomyelitis and the location of the wound in the forefoot predict minor amputation and elevated CRP levels predict major amputation. In the follow-up a low ABI predicts major amputation.


Subject(s)
Diabetic Foot/diagnosis , Diabetic Foot/microbiology , Foot/microbiology , Foot/pathology , Aged , Amputation, Surgical/statistics & numerical data , Ankle Brachial Index , Cohort Studies , Diabetic Foot/pathology , Diabetic Foot/surgery , Female , Follow-Up Studies , Humans , Male , Middle Aged , Predictive Value of Tests , Prognosis , Research Design , Risk Factors , Staphylococcal Infections/complications , Staphylococcal Infections/diagnosis , Staphylococcal Infections/pathology , Staphylococcus aureus/isolation & purification
15.
Enferm Infecc Microbiol Clin ; 34(8): 477-83, 2016 Oct.
Article in Spanish | MEDLINE | ID: mdl-26656792

ABSTRACT

INTRODUCTION: The aim of the study was to assess whether the penetration of antibiotics is affected by decreased tissue perfusion in patients with limb ischaemia, thus reducing its concentration in tissues below the minimum inhibitory concentration (MIC) breakpoints of antibiotics for different microorganisms. METHODS: Prospective study. Candidates for major amputation with critical lower limb ischaemia and an infection on antibiotic treatment, were included. Three levels of perfusion in the lower limb were determined by measuring the transcutaneous oxygen pressure (TcPO2). A central line blood specimen, as well as biopsies of the skin, muscle, and bone, were taken at each perfusion level. The antibiotic concentration was determined using HPLC. RESULTS: The total number of cases was 61 (46 patients): 6 clindamycin, 9 vancomycin, 8 linezolid, 18 levofloxacin, 9 ceftazidime, and 11 meropenem. Statistically significant differences were found in TcPO2 at all levels (ANOVA, P=.000). The vancomycin, levofloxacin and ceftazidime skin concentration depends on perfusion. Vancomycin and levofloxacin diffusion in bone is worse than in other tissues. Ceftazidime concentration does not exceed the MIC breakpoint of Pseudomonas aeruginosa in ischaemic tissues. CONCLUSIONS: Meropenem and linezolid diffuse in all tissues, regardless of perfusion, reaching concentrations above the MIC of the target microorganisms, ensuring its effectiveness in ischaemic tissues.


Subject(s)
Anti-Bacterial Agents/pharmacokinetics , Ischemia/metabolism , Lower Extremity/blood supply , Aged , Ceftazidime , Chromatography, High Pressure Liquid , Clindamycin/pharmacokinetics , Female , Humans , Levofloxacin/pharmacokinetics , Linezolid/pharmacokinetics , Male , Meropenem , Microbial Sensitivity Tests , Prospective Studies , Skin/metabolism , Thienamycins/pharmacokinetics , Vancomycin/pharmacokinetics
16.
Ann Vasc Surg ; 27(8): 1162-8, 2013 Nov.
Article in English | MEDLINE | ID: mdl-23953665

ABSTRACT

BACKGROUND: The therapeutic and diagnostic approach in deep vein thrombosis (DVT) has changed enormously in the last two decades with the introduction of ultrasound, low-molecular-weight heparin (LMWH), and premature motion. The aim of this study is to evaluate these changes and analyze their clinical and economic aspects. METHODS: We registered all inpatients with a diagnosis of DVT during 1994 (n=110) and 2009 (n=75) and their sociodemographic and clinical features in a descriptive observational design. We performed a comparison of diagnostic techniques, length of stay, inpatient complications, and costs thus derived for both series, based on 2009 prices, so that we could get comparable results. RESULTS: Ninety-one percent of inpatients in 1994 were diagnosed by venography, whereas, in 2009, the diagnosis was based on clinical features, D-dimer, and ultrasound in 100% of patients. Inpatient treatment went from 7% LMWH in 1994 to 96% in 2009, and as outpatient from 82% acenocumarol to 90.6% LMWH. Complications decreased by 13.3%. Length of stay was 2.7 higher in 1994. Globally, the cost per patient decreased by 63.39%, based primarily on reduced length of stay. CONCLUSIONS: The current diagnostic and therapeutic approach in DVT allows for effective treatment, fewer complications, and a drastic reduction in inpatient costs.


Subject(s)
Anticoagulants , Heparin, Low-Molecular-Weight , Hospital Costs , Inpatients , Venous Thromboembolism , Adult , Aged , Anticoagulants/economics , Anticoagulants/therapeutic use , Biomarkers/blood , Cost Savings , Cost-Benefit Analysis , Drug Costs , Female , Fibrin Fibrinogen Degradation Products/analysis , Heparin, Low-Molecular-Weight/economics , Heparin, Low-Molecular-Weight/therapeutic use , Humans , Length of Stay/economics , Male , Middle Aged , Models, Economic , Phlebography/economics , Predictive Value of Tests , Registries , Time Factors , Treatment Outcome , Venous Thromboembolism/blood , Venous Thromboembolism/diagnosis , Venous Thromboembolism/economics , Venous Thromboembolism/therapy
17.
Hip Int ; 22(4): 397-402, 2012.
Article in English | MEDLINE | ID: mdl-22865250

ABSTRACT

The purpose of this study was to determine the incidence of arterial false aneurysms following hip surgery diagnosed and treated in our hospital between January 1995 and January 2010. We conducted a retrospective analysis of all patients undergoing hip surgery (osteosynthesis, hemiarthroplasty, total arthroplasty, or revision arthroplasty) under our care. To determine the incidence of arterial false aneurysm, we identified patients with abnormal bleeding through the surgical wound postoperatively. Out of the 11,839 patients undergoing hip surgery during the study period, 321 had abnormal bleeding that aroused suspicion of an associated vascular lesion. Among these, the presence of a false aneurysm requiring specific treatment was confirmed in eight patients. False aneurysms are a rare and occasionally severe complication of hip surgery that typically manifest with significant haemorrhage during the postoperative period. The management of these lesions by interventional radiology is associated with few complications and permits rapid patient stabilisation and early recovery, avoiding more aggressive and sometimes fruitless surgical exploration.


Subject(s)
Aneurysm, False/epidemiology , Arthroplasty/adverse effects , Hip Joint/surgery , Intraoperative Complications/epidemiology , Adult , Aged , Aneurysm, False/diagnosis , Aneurysm, False/therapy , Female , Hip Joint/diagnostic imaging , Humans , Intraoperative Complications/diagnosis , Intraoperative Complications/surgery , Male , Middle Aged , Postoperative Hemorrhage/etiology , Radiography , Retrospective Studies
18.
J Vasc Surg ; 56(3): 808-11, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22579077

ABSTRACT

The main cause of intermittent claudication in lower limbs is peripheral vascular disease. Less commonly, the etiology can be extrinsic to vascular structures, as in the cases of tumors that, due to their rapid growth, can reduce the blood supply and produce intermittent claudication during gait. We report the case of a 49-year-old patient with intermittent claudication in the left lower limb, reporting the presence of a tumor in the inner side of the left thigh with rapid growth. Doppler and angiography magnetic resonance imaging examinations demonstrated the presence of an adipose tumor that was producing deep and superficial extrinsic compression of the femoral arteries.


Subject(s)
Arterial Occlusive Diseases/etiology , Femoral Artery , Intermittent Claudication/etiology , Lipoma/complications , Soft Tissue Neoplasms/complications , Thigh/blood supply , Arterial Occlusive Diseases/diagnosis , Arterial Occlusive Diseases/physiopathology , Constriction, Pathologic , Female , Femoral Artery/diagnostic imaging , Femoral Artery/pathology , Femoral Artery/physiopathology , Hemodynamics , Humans , Intermittent Claudication/diagnosis , Intermittent Claudication/physiopathology , Lipoma/diagnosis , Lipoma/surgery , Magnetic Resonance Angiography , Middle Aged , Predictive Value of Tests , Soft Tissue Neoplasms/diagnosis , Soft Tissue Neoplasms/surgery , Treatment Outcome , Tumor Burden , Ultrasonography, Doppler, Duplex
19.
J Surg Res ; 174(1): e1-e10, 2012 May 01.
Article in English | MEDLINE | ID: mdl-22099599

ABSTRACT

OBJECTIVES: The myocardium of patients with diabetes and poor left ventricular (LV) function cannot be protected by interventions such as ischemic preconditioning (IP). We investigated whether these clinical conditions influence the protection elicited by the paracrine effect of bone marrow cells (BMCs) and whether the cause for loss in protection resides in the BMCs, the myocardium, or both. METHODS: BMCs and right atrial appendage were obtained from patients with and without diabetes and from poor (EF < 30%) and preserved LV function undergoing elective cardiac surgery. Muscles (n = 6/group) were co-cultured with BMCs and subjected to 90 min ischemia/120 min reoxygenation at 37°C. The degree of protection was assessed by measuring creatine kinase (CK) released, and myocardial cell necrosis and apoptosis. RESULTS: Ischemia-induced CK release, cell necrosis, and apoptosis in the diabetic myocardium were not significantly affected by IP or by co-incubation with autologous or non-diabetic allogenic BMCs. Conversely, significant reduction in CK release, cell necrosis, and apoptosis were observed when non-diabetic myocardium was co-incubated with allogenic diabetic BMCs. Interestingly, while allogenic BMCs from subjects with preserved LV function exerted a modest but significant reduction in CK leakage and cell necrosis, but not apoptosis, on failing myocardium, the BMCs from patients with poor LV function failed to protect their own and the allogenic myocardium from subjects with normal LV function. CONCLUSIONS: The failure to protect the myocardium of patients with poor LV function against ischemia/reoxygenation-induced injury is mainly due to a deficit in their BMCs and the myocardium itself, whereas in patients with diabetes the deficit remains within the myocardium and not in the BMCs.


Subject(s)
Bone Marrow Cells/physiology , Diabetes Mellitus/physiopathology , Ischemic Preconditioning, Myocardial , Myocardial Reperfusion Injury/prevention & control , Ventricular Function, Left , Adult , Aged , Aged, 80 and over , Humans , Middle Aged
20.
J Physiol ; 588(Pt 12): 2173-91, 2010 Jun 15.
Article in English | MEDLINE | ID: mdl-20403980

ABSTRACT

Protein kinase B (PKB/Akt) plays a critical role in cell survival but the investigation of its involvement has been limited by the lack of specific pharmacological agents. In this study, using novel PKB inhibitors (VIII and XI), we investigated the role of PKB in cardioprotection of the rat and human myocardium, the location of PKB in relation to mitoK(ATP) channels and p38 mitogen-activated protein kinase (p38 MAPK), and whether the manipulation of PKB can overcome the unresponsiveness to protection of the diabetic myocardium. Myocardial slices from rat left ventricle and from the right atrial appendage of patients undergoing elective cardiac surgery were subjected to 90 min ischaemia/120 min reoxygenation at 37 degrees C. Tissue injury was assessed by creatine kinase (CK) released and determination of cell necrosis and apoptosis. The results showed that blockade of PKB activity caused significant reduction of CK release and cell death, a benefit that was as potent as ischaemic preconditioning and could be reproduced by blockade of phosphatidylinositol 3-kinase (PI-3K) with wortmannin and LY 294002. The protection was time dependent with maximal benefit seen when PKB and PI-3K were inhibited before ischaemia or during both ischaemia and reoxygenation. In addition, it was revealed that PKB is located downstream of mitoK(ATP) channels but upstream of p38 MAPK. PKB inhibition induced a similar degree of protection in the human and rat myocardium and, importantly, it reversed the unresponsiveness to protection of the diabetic myocardium. In conclusion, inhibition of PKB plays a critical role in protection of the mammalian myocardium and may represent a clinical target for the reduction of ischaemic injury.


Subject(s)
Myocardial Reperfusion Injury/prevention & control , Myocardium/enzymology , Protein Kinase Inhibitors/pharmacology , Proto-Oncogene Proteins c-akt/antagonists & inhibitors , Adult , Aged , Aged, 80 and over , Animals , Apoptosis , Creatine Kinase/metabolism , Dose-Response Relationship, Drug , Female , Humans , In Vitro Techniques , Male , Middle Aged , Myocardial Reperfusion Injury/enzymology , Myocardial Reperfusion Injury/pathology , Myocardium/pathology , Necrosis , Phosphatidylinositol 3-Kinases/metabolism , Phosphoinositide-3 Kinase Inhibitors , Phosphorylation , Potassium Channels/metabolism , Proto-Oncogene Proteins c-akt/metabolism , Rats , Rats, Wistar , Serine , Time Factors , p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors , p38 Mitogen-Activated Protein Kinases/metabolism
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