ABSTRACT
The kinetics of a spontaneous peripheral blood neutrophilic nitroblue tetrazolium test (NBT-test) has been studied in neonatal infants. The reaction is shown to come to an end after 60-min reaction mixture thermostating, thereafter the proportion of activated neutrophils (PAN) does not change (PAN(infinity)). The reaction is described using the first-order kinetic equation that is similar to that having the rate constant k1. The calculations of PAN(infinity) and k1 allow a differential diagnosis of bacterial infections with and/or without pneumonia.
Subject(s)
Infant, Newborn, Diseases/diagnosis , Neutrophil Activation , Neutrophils , Nitroblue Tetrazolium/chemistry , Pneumonia, Bacterial/diagnosis , Female , Humans , Infant, Newborn , Infant, Newborn, Diseases/immunology , Male , Neutrophil Activation/immunology , Neutrophils/immunology , Pneumonia, Bacterial/immunologyABSTRACT
The population prevalence of congenital hypertrophic pyloric stenosis in Donetsk region in the course of 11 years (1989-1999) has been descriptively studied. Its frequency is 0.73:1000 or 1:1370 newborn infants annual with range of 0.54 to 1.01:1000. It is somewhat lower than that of more wide spread congenital diseases: labial cleft and hemochromatoses. Pyloric stenosis is detected in 42 of 43 populations of Donetsk region. There is a population nonuniformity of the case rate: from 0.19 to 1.9:1000 newborn infants, that the authors are inclined to explain by dissimilarity of a gene pool in the populations due to random migration of the population.
