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2.
Med Phys ; 49(2): 1286-1296, 2022 Feb.
Article in English | MEDLINE | ID: mdl-34905630

ABSTRACT

BACKGROUND: The microdosimetric quantity lineal energy and its mean values have proven useful for quantifying radiation quality in many situations. The ratio of dose-mean lineal energies is perhaps the simplest quantity for quantifying differences between two radiation qualities. However, published dose-mean lineal energy values from different codes may differ significantly with potential influence on radiation quality estimates. PURPOSE: The purpose was to compare dose-mean lineal energy values from different track-structure data sets for condensed water vapor and liquid water, and to evaluate the influence on radiation quality estimations for some photon sources. METHODS: Published dose-mean lineal energy values for 0.1 keV to 1 MeV electrons in spheres with diameters 2 nm to 1 µm, calculated with water vapor and liquid water track structure codes and proximity functions, were collected, analyzed, and compared. Data for cylinders were converted to spheres using a theoretical transformation published by Kellerer. A new set of dose-mean lineal energy values was calculated to cover the whole range of volumes of interest here using the GEANT4-DNA code. The influence from the differences between codes on radiation quality calculations was estimated using dose-mean lineal energy ratios for the photon sources 125 I, 169 Yb, and 192 Ir relative to 60 Co. RESULTS: The theoretical relation for converting the dose-mean lineal energy between different geometrical volumes, results in differences up to 10% between cylinders and spheres depending on electron energy and target size, in agreement with published simulated results. For spheres with diameter above 100 nm, dose-mean lineal energy values for condensed water vapor and liquid water are with few exceptions within ±10%. Below 100 nm, the difference increases with decreasing diameter reaching a factor of two at 2 nm. The values from water vapor codes are in general larger than from liquid water codes. If the dose-mean lineal energy ratio is based on condensed water vapor instead of liquid water, the ratio differs less than 9% for the nuclides 125 I, 169 Yb, and 192 Ir relative to 60 Co independent of the volume simulated. However, a specific value of the dose-mean lineal energy ratio, is found at a larger target diameter in liquid water than in condensed water vapor. CONCLUSIONS: When ratios of the dose-mean lineal energy are used as a measure of the radiation quality it is important to compare values for geometrically equal target shapes. A practical method of converting values for cylinders of equal diameter and height to spheres was demonstrated. Although dose-mean lineal energy values calculated with water vapor and liquid water codes may differ significantly, the radiation quality, in terms of ratios of dose-mean lineal energy, for the three photon sources 192 Ir, 169 Yb, and 125 I relative to 60 Co, agree within 9%. The same ratio appears at a larger diameter when a liquid water code is used. It is therefore important to use the same code in radiation quality investigations. The present findings may be of special interest in studies related to the relative biological effectiveness (RBE).


Subject(s)
Electrons , Radiometry , Monte Carlo Method , Photons , Relative Biological Effectiveness
3.
Phys Med Biol ; 60(21): 8621-4, 2015 Nov 07.
Article in English | MEDLINE | ID: mdl-26501784

ABSTRACT

The relative standard deviation, σr,D, of calculated multi-event distributions of specific energy for (60)Co ϒ rays was reported by the authors F Villegas, N Tilly and A Ahnesjö (Phys. Med. Biol. 58 6149-62). The calculations were made with an upgraded version of the Monte Carlo code PENELOPE. When the results were compared to results derived from experiments with the variance method and simulated tissue equivalent volumes in the micrometre range a difference of about 50% was found. Villegas et al suggest wall-effects as the likely explanation for the difference. In this comment we review some publications on wall-effects and conclude that wall-effects are not a likely explanation.


Subject(s)
Brachytherapy/methods , Cell Nucleus/radiation effects , Environmental Exposure/analysis , Iridium Radioisotopes/therapeutic use , Monte Carlo Method
4.
Radiat Prot Dosimetry ; 166(1-4): 339-42, 2015 Sep.
Article in English | MEDLINE | ID: mdl-25953788

ABSTRACT

In a recent paper, the authors reported that the dose mean lineal energy, [Formula: see text] in a volume of about 10-15 nm is approximately proportional to the α-parameter in the linear-quadratic relation used in fractionated radiotherapy in both low- and high-LET beams. This was concluded after analyses of reported radiation weighting factors, WisoE (clinical RBE values), and [Formula: see text] values in a large range of volumes. Usually, microdosimetry measurements in the nanometer range are difficult; therefore, model calculations become necessary. In this paper, the authors discuss the calculation method. A combination of condensed history Monte Carlo and track structure techniques for calculation of mean lineal energy values turned out to be quite useful. Briefly, the method consists in weighting the relative dose fractions of the primary and secondary charged particles with their respective energy-dependent dose mean lineal energies. The latter were obtained using a large database of Monte Carlo track structure calculations.


Subject(s)
Linear Energy Transfer/radiation effects , Nanotechnology/methods , Neoplasms/radiotherapy , Particle Accelerators/instrumentation , Radiometry/instrumentation , Relative Biological Effectiveness , Computer Simulation , Humans , Models, Biological , Monte Carlo Method , Radiometry/methods , Radiotherapy Dosage
5.
Med Phys ; 41(8): 081721, 2014 Aug.
Article in English | MEDLINE | ID: mdl-25086531

ABSTRACT

PURPOSE: To investigate microdosimetry properties of 160 MeV/u protons and 290 MeV/u(12)C ion beams in small volumes of diameters 10-100 nm. METHODS: Energy distributions of primary particles and nuclear fragments in the beams were calculated from simulations with the general purpose code SHIELD-HIT, while energy depositions by monoenergetic ions in nanometer volumes were obtained from the event-by-event Monte Carlo track structure ion code PITS99 coupled with the electron track structure code KURBUC. RESULTS: The results are presented for frequencies of energy depositions in cylindrical targets of diameters 10-100 nm, dose distributions yd(y) in lineal energy y, and dose-mean lineal energies yD. For monoenergetic ions, the yD was found to increase with an increasing target size for high-linear energy transfer (LET) ions, but decrease with an increasing target size for low-LET ions. Compared to the depth dose profile of the ion beams, the maximum of the yD depth profile for the 160 MeV proton beam was located at ∼ 0.5 cm behind the Bragg peak maximum, while the yD peak of the 290 MeV/u (12)C beam coincided well with the peak of the absorbed dose profile. Differences between the yD and dose-averaged linear energy transfer (LETD) were large in the proton beam for both target volumes studied, and in the (12)C beam for the 10 nm diameter cylindrical volumes. The yD determined for 100 nm diameter cylindrical volumes in the (12)C beam was approximately equal to the LETD. The contributions from secondary particles to the yD of the beams are presented, including the contributions from secondary protons in the proton beam and from fragments with atomic number Z = 1-6 in the (12)C beam. CONCLUSIONS: The present investigation provides an insight into differences in energy depositions in subcellular-size volumes when irradiated by proton and carbon ion beams. The results are useful for characterizing ion beams of practical importance for biophysical modeling of radiation-induced DNA damage response and repair in the depth profiles of protons and carbon ions used in radiotherapy.


Subject(s)
Carbon , Ions , Microtechnology/methods , Protons , Radiometry/methods , Computer Simulation , Linear Energy Transfer , Monte Carlo Method , Radiation Dosage , Water
6.
Phys Med Biol ; 55(10): R65-109, 2010 May 21.
Article in English | MEDLINE | ID: mdl-20427859

ABSTRACT

Relative biological effectiveness (RBE) compares the severity of damage induced by a radiation under test at a dose D relative to the reference radiation D(x) for the same biological endpoint. RBE is an important parameter in estimation of risk from exposure to ionizing radiation (IR). The present work provides a review of the recently published data and the knowledge of the RBE of low energy electrons and photons. The review presents RBE values derived from experimental data and model calculations including cell inactivation, chromosome aberration, cell transformation, micronuclei formation and induction of double-strand breaks. Biophysical models, including physical features of radiation track, and microdosimetry parameters are presented, analysed and compared with experimental data. The biological effects of low energy electrons and photons are of particular interest in radiation biology as these are strongly absorbed in micrometer and sub-micrometer layers of tissue. RBE values not only depend on the electron and photon energies but also on the irradiation condition, cell type and experimental conditions.


Subject(s)
Electrons , Photons , Animals , Biophysical Phenomena/radiation effects , Cells/cytology , Cells/metabolism , Cells/pathology , Cells/radiation effects , Humans , Relative Biological Effectiveness , X-Rays
8.
Radiat Prot Dosimetry ; 118(2): 182-9, 2006.
Article in English | MEDLINE | ID: mdl-16581920

ABSTRACT

In May 2000, the chairman of the European Radiation Dosimetry Group (EURADOS) invited a number of experts with experience of cosmic radiation dosimetry to form a working group (WG 5) on aircraft crew dosimetry. Three observers from the Article 31 Group of Experts as well as one observer from the Joint Aviation Authorities (JAA) were also appointed. The European Commission funded the meetings. Full meetings were organised in January 2001 and in November 2001. An editorial group, who are the authors of this publication, started late in 2002 to finalise a draft report, which was submitted to the Article 31 Group of Experts in June 2003. The methods and data reported are the product of the work of 26 research institutes from the EU, USA and Canada. Some of the work was supported by contracts with the European Commission, Directorate General XII, Science, Research and Development. A first overview of the EC report was published late in 2004. In this publication we focus on a comparison of measured and calculated ambient dose rate data using the EURADOS In-Flight Data Base. The evaluation of results obtained by different methods and groups, and comparison of measurement results and the results of calculations were performed in terms of the operational quantity ambient dose equivalent, H*(10). Aspects of measurement uncertainty are reported also. The paper discusses the estimation of annual doses for given flight hours and gives an outline of further research needed in the field of aircraft crew dosimetry, such as the influence of solar particle events.


Subject(s)
Radiometry/methods , Radiometry/standards , Aerospace Medicine , Aircraft , Aviation , Calibration , Cosmic Radiation , Europe , Humans , Occupational Exposure , Radiation , Radiation Dosage , Radiation Monitoring/methods , Radiation Monitoring/standards
9.
Radiat Prot Dosimetry ; 110(1-4): 417-22, 2004.
Article in English | MEDLINE | ID: mdl-15353684

ABSTRACT

The aim of the working group has been to bring together, in particular from European research groups, the available, preferably published, experimental data and results of calculations, together with detailed descriptions of the methods of measurement and calculation. The purpose is to provide a dataset for all European Union Member States for the assessment of individual doses and/or to assess the validity of different approaches, and to provide an input to technical recommendations by the Article 31 group of experts and the European Commission. The radiation protection quantity of interest is effective dose, E (ISO), but the comparison of measurement results obtained by different methods or groups, and comparison of measurement results and the results of calculations, is done in terms of the operational quantity ambient dose equivalent, H*(10). The final report giving the results of the investigations will be published by the European Commission Directorate General Transport and Energy. This paper gives a preview of the report.


Subject(s)
Aircraft , Algorithms , Cosmic Radiation , Neutrons , Occupational Exposure/analysis , Radiometry/methods , Risk Assessment/methods , Body Burden , Computer Simulation , European Union , Internationality , Models, Biological , Occupational Exposure/standards , Radiation Dosage , Radiation Protection/methods , Radiation Protection/standards , Radiometry/standards , Relative Biological Effectiveness , Reproducibility of Results , Risk Assessment/standards , Risk Factors , Sensitivity and Specificity
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