Pregnancy and fetal outcome in women with primary Sjogren's syndrome compared with women in the general population: a nested case-control study.

OBJECTIVE: To study pregnancy and fetal outcome in women with primary SS (pSS) compared with women in the general population. METHODS: In a nested case-control setting, variables related to pregnancy and fetal outcomes were compared. Cases (n = 16) were identified through registry linkage (Malmö pSS registry and a database entailing information of all pregnancies and deliveries in Malmö from 1990 through 2006). For each pregnancy with pSS, the following five deliveries from the same registry were chosen as controls (n = 80). RESULTS: All cases fulfilled the American European Consensus Criteria for pSS and were positive for ANA and anti-SSA antibodies. Date of diagnosis was before pregnancy in 10 women and after delivery in 6. Mean age at delivery was significantly higher in women with pSS (33.6 years) vs controls (29.8 years). While pregnancy duration did not differ, mean birthweight was significantly lower in offspring of pSS mothers (3010 g) vs babies of control mothers (3458 g). Normal partus in contrast to vacuum extraction or Caesarean section was significantly more frequent in healthy women than in pSS women (83 vs 56%). Other pregnancy outcomes such as parity, miscarriages and Apgar score did not differ. There were no significant differences between women with a pSS diagnosis before or after the index pregnancy. Only one of the included pregnancies was complicated by intrauterine AV block. CONCLUSION: Pregnancy occurs later in life in pSS women. Mothers with pSS give birth to offspring with lower birthweight and less commonly have normal partus.

Fetal biometry between 20-42 weeks of gestation for Polish population.

OBJECTIVE: Ultrasound estimating of fetal weight is one of the most frequent examinations during pregnancy. Hitherto, foreign fetometry curves have mostly been used in Poland as there are no national available reference charts that are based on ultrasound fetal biometry. The aim of the present study was to construct new charts based on ultrasound fetometry reference for Polish population. STUDY DESIGN: A group of 959 healthy volunteers with uncomplicated singleton pregnancy joined in a cross-sectional study. The study was designed prospectively to evaluate normal reference charts for fetal ultrasound measurements and estimated fetal weight. Four biometric parameters were studied: biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC) and femur length (FL). Estimated fetal weight (EFW) was calculated using Hadlock et al. formula from 1985. RESULTS: In the course of normal pregnancy an acceleration of growth rate was seen, but with a slight decline at the end of pregnancy. Reference curves for mean, 90th and 95th percentile were constructed for BPD, HC, AC and FL. Estimated fetal weight curves were outlined for both boys and girls. CONCLUSION: Reference charts for Polish population are similar to foreign curves. Less variation was seen in comparison with national charts based on postnatal weight. Ultrasound method seems to be better than birthweight curves especially in preterm pregnancies. This will improve the diagnosis of a small for gestational age newborn.