1.
Bioorg Med Chem Lett
; 12(24): 3565-7, 2002 Dec 16.
Article
in English
| MEDLINE
| ID: mdl-12443777
ABSTRACT
A series of 5-substituted 2-benzoylaminobenzoic acids has been synthesized and assayed for PPARalpha/gamma activity. Both dual activators and selective PPARgamma agonists have been identified. This class of compounds was shown to activate the PPARgamma receptor through interaction with a novel binding site.
Subject(s)
Aminobenzoates/chemical synthesis , Aminobenzoates/pharmacology , Receptors, Cytoplasmic and Nuclear/agonists , Transcription Factors/agonists , Binding Sites , Crystallography, X-Ray , Humans , Receptors, Cytoplasmic and Nuclear/genetics , Structure-Activity Relationship , Transcription Factors/genetics , Transcriptional Activation/drug effects , Transfection , Tumor Cells, Cultured
2.
World health
; 49(5): 9-1996-09.
Article
in English
| WHO IRIS
| ID: who-330518
3.
World health
; 48(5): 3-1995-09.
Article
in English
| WHO IRIS
| ID: who-330232
