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1.
Unusual reagent control of diastereoselectivity in the 1,2-addition of hard carbon nucleophiles to C(6)-heteroatom substituted cyclohexenones.
Lindsay, H A; Salisbury, C L; Cordes, W; McIntosh, M C.
Org Lett ; 3(25): 4007-10, 2001 Dec 13.
Article in English | MEDLINE | ID: mdl-11735571

ABSTRACT

[reaction: see text] A surprising and synthetically useful counterion-dependent reversal of diastereoselectivity was found in 1,2-additions of hard carbon nucleophiles to C(6)-heterosubstituted cyclohexenones. In general, Grignard reagents added syn to the C(6)-substituent and Li reagents added anti, although some exceptions were found. Selectivities could be increased in some cases by appropriate choice of solvent and/or cosolvent.


Subject(s)
Hydrocarbons, Cyclic/chemistry , Antineoplastic Agents, Phytogenic/chemistry , Carbazoles , Cyclohexanones/chemistry , Diterpenes , Indoles/chemistry , Lithium/chemistry , Magnesium Compounds/chemistry , Molecular Conformation , Molecular Structure , Pyrroles/chemistry , Spiro Compounds/chemistry , Stereoisomerism
2.
Effect of exogenous triiodothyronine on weight and composition of the heart in rats.
Mowery, M B; Lindsay, H A.
Proc Soc Exp Biol Med ; 143(1): 138-40, 1973 May.
Article in English | MEDLINE | ID: mdl-4267368

Subject(s)
Cardiomegaly/chemically induced , Heart/drug effects , Triiodothyronine/pharmacology , Animals , Cardiomegaly/etiology , Collagen/metabolism , Hydroxyproline/metabolism , Male , Myocardium/analysis , Myocardium/metabolism , Organ Size , Rats
3.
Uptake of tritium-labelled testosterone by rat femur: effect of disuse and age.
Grant, M A; Lindsay, H A; Thomas, J A.
Can J Physiol Pharmacol ; 49(7): 717-9, 1971 Jul.
Article in English | MEDLINE | ID: mdl-5141691

Subject(s)
Femur/metabolism , Testosterone/metabolism , Age Factors , Analysis of Variance , Animals , Atrophy/etiology , Bone Diseases/etiology , Femur/analysis , Immobilization , Injections, Intraperitoneal , Male , Rats , Time Factors , Tritium
4.
Changes in bone in experimental aortic or pulmonary stenosis.
Broadwater, R L; Lindsay, H A.
Br J Exp Pathol ; 49(4): 375-8, 1968 Aug.
Article in English | MEDLINE | ID: mdl-5676447

Subject(s)
Aortic Valve Stenosis/complications , Bone Diseases/etiology , Pulmonary Valve Stenosis/complications , Animals , Biomechanical Phenomena , Biometry , Bone and Bones/analysis , Elasticity , Femur/analysis , Organ Size , Rats
5.
Age as a determinant of the effect of testosterone upon disuse osteoporosis of paralyzed limbs of rats.
Bullard, T R; Lindsay, H A.
Can J Physiol Pharmacol ; 46(4): 689-91, 1968 Jul.
Article in English | MEDLINE | ID: mdl-5668216

Subject(s)
Age Factors , Osteoporosis , Paralysis , Testosterone/pharmacology , Animals , Animals, Newborn , Atrophy , Bone and Bones/drug effects , Denervation , Hindlimb , Osteoporosis/complications , Paralysis/complications , Rats
6.
Simulated aortic or pulmonary stenosis in the rat.
Stewart, P S; Lindsay, H A.
Proc Soc Exp Biol Med ; 125(2): 363-7, 1967 Jun.
Article in English | MEDLINE | ID: mdl-6028546

Subject(s)
Aortic Valve Stenosis/physiopathology , Appetite , Pulmonary Valve Stenosis/physiopathology , Animals , Appetite Regulation , Body Composition , Body Constitution , Body Weight , Growth , Male , Rats
7.
Statistical analysis in toxicity experiments.
Lindsay, H A.
Science ; 152(3726): 1282-3, 1966 May 27.
Article in English | MEDLINE | ID: mdl-5937124

Subject(s)
Pentobarbital/toxicity , Statistics as Topic , Animals , Mice
8.
Pentobarbital sodium: variation in toxicity.
Lindsay, H A; Kullman, V S.
Science ; 151(3710): 576-7, 1966 Feb 04.
Article in English | MEDLINE | ID: mdl-5903582

ABSTRACT

The survival rate of groups of female mice given a standard dose of pentobarbital sodium varied during a 12-hour period. When survival rate was plotted against time, a curve with several inflections was described.


Subject(s)
Pentobarbital/toxicity , Animals , Injections, Intraperitoneal , Mice , Mortality , Periodicity , Time
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