1.
Bioorg Med Chem Lett
; 9(2): 145-50, 1999 Jan 18.
Article
in English
| MEDLINE
| ID: mdl-10021917
ABSTRACT
All four "symmetrical" regioisomers of ED-110, an indolocarbazole derivative having potent activity against human topoisomerase I (Topo I) were synthesized. The isomer containing hydroxyl groups in the 3- and 9-positions was approximately ten-fold more active against Topo I, and 5- to 35-fold more active against human solid tumor cell lines in vitro, relative to ED-110.
