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Desacetyluvaricin from Uvaria accuminata, configuration of uvaricin at C-36.

Jolad, S D; Hoffmann, J J; Cole, J R; Barry, C E; Bates, R B; Linz, G S; Konig, W A.

J Nat Prod ; 48(4): 644-5, 1985.

Article in English | MEDLINE | ID: mdl-3840199

Subject(s)

Antineoplastic Agents, Phytogenic , Furans , Hydrolysis , Magnetic Resonance Spectroscopy , Molecular Conformation , Ozone

Microbial transformations of natural antitumor agents XXII: Conversion of bouvardin to O-desmethylbouvardin and bouvardin catechol.

Petroski, R J; Bates, R B; Linz, G S; Rosazza, J P.

J Pharm Sci ; 72(11): 1291-4, 1983 Nov.

Article in English | MEDLINE | ID: mdl-6644590

ABSTRACT

Bouvardin is a cyclic hexapeptide antitumor agent which undergoes two major microbial transformation reactions. Screening with 220 cultures revealed 17 different strains capable of producing O-desmethylbouvardin in good yield. O-Desmethylbouvardin was isolated and characterized from preparative scale incubations with Streptomyces rutgersensis NRRL B-1256. Four aspergilli and one streptomycete formed bouvardin catechol when O-desmethylbouvardin was used as substrate. Bouvardin catechol was isolated and characterized from a preparative scale incubation with Aspergillus ochraceous UI 398.

Subject(s)

Antineoplastic Agents, Phytogenic/metabolism , Peptides, Cyclic/metabolism , Aspergillus/metabolism , Biotransformation , Fermentation , Magnetic Resonance Spectroscopy , Mass Spectrometry , Streptomyces/metabolism

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ABSTRACT

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