ABSTRACT
Retransfusion of a patient's own shed blood during cardiac surgery is attractive since it reduces the need for allogeneic transfusion, minimizes cost, and decreases transfusion related morbidity. Evidence suggests that lipid micro-emboli associated with the retransfusion of the shed blood are the predominant causes of the neurocognitive disorders. We have developed a novel acoustophoretic filtration system that can remove lipids from blood at clinically relevant flow rates. Unlike other acoustophoretic separation systems, this ultrasound technology works at the macroscale, and is therefore able to process larger flow rates than typical micro-electromechanical system (MEMS) scale acoustophoretic separation devices. In this work, we have first demonstrated the systematic design of the acoustic device and its optimization, followed by examining the feasibility of the device to filter lipids from the system. Then, we demonstrate the effects of the acoustic waves on the shed blood; examining hemolysis using both haptoglobin formation and lactate dehydrogenase release, as well as the potential of platelet aggregation or inflammatory cascade activation. Finally, in a porcine surgical model, we determined the potential viability of acoustic trapping as a blood filtration technology, as the animal responded to redelivered blood by increasing both systemic and mean arterial blood pressure.
ABSTRACT
Sonic boom propagation can be affected by atmospheric turbulence. It has been shown that turbulence affects the perceived loudness of sonic booms, mainly by changing its peak pressure and rise time. The models reported here describe the nonlinear propagation of sound through turbulence. Turbulence is modeled as a set of individual realizations of a random temperature or velocity field. In the first model, linear geometrical acoustics is used to trace rays through each realization of the turbulent field. A nonlinear transport equation is then derived along each eigenray connecting the source and receiver. The transport equation is solved by a Pestorius algorithm. In the second model, the KZK equation is modified to account for the effect of a random temperature field and it is then solved numerically. Results from numerical experiments that simulate the propagation of spark-produced N waves through turbulence are presented. It is observed that turbulence decreases, on average, the peak pressure of the N waves and increases the rise time. Nonlinear distortion is less when turbulence is present than without it. The effects of random vector fields are stronger than those of random temperature fields. The location of the caustics and the deformation of the wave front are also presented. These observations confirm the results from the model experiment in which spark-produced N waves are used to simulate sonic boom propagation through a turbulent atmosphere.
Subject(s)
Acoustics , Loudness Perception , Models, Theoretical , Sound , TemperatureABSTRACT
In previous papers, we have shown that model experiments are successful in simulating the propagation of sonic booms through the atmospheric turbulent boundary layer. The results from the model experiment, pressure wave forms of spark-produced N waves and turbulence characteristics of the plane jet, are used to test various sonic boom models for propagation through turbulence. Both wave form distortion models and rise time prediction models are tested. Pierce's model [A. D. Pierce, "Statistical theory of atmospheric turbulence effects on sonic boom rise times," J. Acoust. Soc. Am. 49, 906-924 (1971)] based on the wave front folding mechanism at a caustic yields an accurate prediction for the rise time of the mean wave form after propagation through the turbulence.
