[Effects of nonoxinol 9 on RFLP typing of postcoital vaginal smears]. / Auswirkungen von Nonoxinol 9 auf die RFLP-Typisierung postkoitaler Vaginalabstriche.

Nonoxinol 9 effectively inactivates high titres of HIV in vitro, which suggest its use for reducing HIV-transmission via sexual intercourse. Therefore, the suggestion has been made for the treatment of sexual assault victims with a topical anti-HIV agent such as nonoxinol 9 as soon as possible after a sexual assault has occurred. From the forensic point of view it becomes pertinent to determine whether or not nonoxinol 9 would have an adverse effect on the high-molecular weight deoxyribonucleic acid (DNA) in vaginal swabs and thereby impact RFLP results. The study demonstrates that nonoxinol 9 does not have a negative effect on the ability to produce RFLP patterns. Therefore, the early administration of the topical anti-HIV agent nonoxinol 9 has to be considered as an important step in the medical treatment of sexual assault victims.

[Fatal intracranial increase in pressure caused by a colloid cyst of the 3d ventricle not diagnosed intra vitam]. / Tödliche intrakranielle Drucksteigerung durch eine intra vitam nicht diagnostizierte Kolloidzyste des III. Ventrikels.

The case is reported of a 26 year-old man with a colloid cyst of the third ventricle (paraphyseal cyst; neuroepithelial cyst), which gave rise to a fatal increase in intracranial pressure. Despite repeated hospitalisation the diagnosis was not established prior to death. This report serves as a reminder that this rare disorder must be considered in the differential diagnosis of conditions causing increased intracranial pressure in view of the life-saving therapeutic management required to avert a fatal outcome.