ABSTRACT
Malignant fibrous histiocytoma is a rare sarcoma. Only seven cases in the vulva have been reported. We present a case of malignant fibrous histiocytoma of the vulva in an adolescent female. The elected treatment was local wide resection.
Subject(s)
Histiocytoma, Benign Fibrous/pathology , Vulvar Neoplasms/pathology , Adolescent , Cell Differentiation , Female , Histiocytoma, Benign Fibrous/surgery , Humans , Vulvar Neoplasms/surgeryABSTRACT
A 56-year-old woman presented with orbital signs and symptoms suggestive of lacrimal gland tumor. An excised biopsy specimen was obtained and showed glandular tissue, which could be confused with lacrimal gland acini. Closer microscopic examination and immunohistochemical studies revealed a metastatic tumor of thyroid gland origin. Initially, there was no identifiable nodule in the thyroid, but 3 months later a thyroid nodule was found by ultrasound and radioisotope scan. The histopathologic appearance of the thyroid nodule was similar to that found in the orbit. This case demonstrates the usefulness of immunohistochemistry in establishing a diagnosis when the microscopic appearance is inconclusive.
Subject(s)
Adenocarcinoma/diagnosis , Lacrimal Apparatus , Orbital Neoplasms/secondary , Thyroid Neoplasms/diagnosis , Adenocarcinoma/pathology , Adenocarcinoma/secondary , Biopsy , Exophthalmos/diagnosis , Female , Humans , Immunoenzyme Techniques , Lacrimal Apparatus Diseases/diagnosis , Lacrimal Apparatus Diseases/pathology , Middle Aged , Orbital Neoplasms/diagnosis , Orbital Neoplasms/pathology , Thyroglobulin/immunology , Thyroid Neoplasms/pathology , Tomography, X-Ray ComputedABSTRACT
Two biopsies of an erosive lesion of the nipple had an appearance of an acantholytic disease without showing malignant cells. Only a third biopsy through the nipple with removal of a larger portion revealed some nests of atypical, large cells with clear cytoplasm, typical of Paget's disease. Immunohistochemical findings with carcinoembryonic antigen confirmed the diagnosis of Paget's disease of the nipple. This is the first case of Paget's disease which shows extensive acantholysis on microscopic examination and which resembles pemphigus vulgaris histologically. Acantholytic diseases are easily distinguished from Paget's disease and have never been mentioned in the differential diagnosis of this disease. A large biopsy through the nipple with the removal of a liberal portion of the nipple is suggested in every case of a suspected unilateral lesion of the nipple in order to avoid the overlooking of small nests of Paget's cells, as in our first biopsies, showing a histological picture of an acantholytic disease.
Subject(s)
Breast Neoplasms/pathology , Breast , Carcinoma, Intraductal, Noninfiltrating/pathology , Nipples , Paget's Disease, Mammary/pathology , Acantholysis/diagnosis , Acantholysis/pathology , Adult , Biopsy , Breast/pathology , Breast Neoplasms/diagnosis , Diagnosis, Differential , Female , Humans , Nipples/pathology , Paget's Disease, Mammary/diagnosisABSTRACT
A young man who had suffered from rheumatoid arthritis developed a huge cervicothoracic aneurysmal bone cyst and progressive quadriparesis. Complete recovery occurred after "incomplete therapy," which consisted of an open biopsy and a small dose of irradiation. This tumor was observed and characterized as a blood-filled cyst excavated from the bone. Because of the controversy in the literature over the benefit of surgery vs. irradiation, this report emphasizes the fact that even "partial" treatment may beneficially affect this tumor.
Subject(s)
Bone Cysts/complications , Quadriplegia/etiology , Spinal Diseases/complications , Adolescent , Angiography , Biopsy , Bone Cysts/diagnostic imaging , Bone Cysts/pathology , Bone Cysts/surgery , Humans , Male , Spinal Diseases/diagnostic imaging , Spinal Diseases/pathology , Spinal Diseases/surgery , Tomography, X-Ray ComputedABSTRACT
Hyperostosis (lipping) due to costovertebral arthritis was found frequently (84.3%) impinging on the sympathetic trunks (ganglia and cord), rami communicantes and roots of the splanchnic nerves on both sides of the spine in more than 1,000 dissecting room cadavers examined and 34 cadavers of adult and elderly people specially dissected. As a result of the compression, the affected sympathetic structures were angulated, deflected from their course, enlarged and often infiltrated with connective tissue. The possible symptoms which may result from this kind of compression are discussed.
Subject(s)
Arthritis/pathology , Joints/pathology , Sympathetic Nervous System/pathology , Thoracic Vertebrae/pathology , Arthritis/complications , Cadaver , Female , Humans , Male , Nerve Compression Syndromes/diagnosis , Nerve Compression Syndromes/etiology , Sympathetic Nervous System/injuries , Thoracic Vertebrae/cytologyABSTRACT
A 23 year old woman suffering from grand mal epilepsy showed generalized spike and wave activity on her EEG. The CT showed a cystic tumor in the cortex and the white tissue of the right parietal region. On operation the tumor was diagnosed as malignant infiltrating cystic meningioma. After removal of the tumor the spike and wave pattern disappeared. Cortical localized tumors are rarely associated with a generalized spike and wave pattern.