[Optimization of conservation regimes and processes of regeneration of organs and tissues in surgery and transplantology using mathematical methods of planning experiments]. / Optimizatsiia rezhimov konservirovaniia i protsessov regeneratsii organov i tkanei v khirurgii i transplantologii s ispol'zovaniem matematicheskikh metodov planirovaniia éksperimenta.

The experience of using mathematical planning of an experiment in solving problems of multifactor optimisation in surgery and transplantology is discussed, including optimisation of heart and bone tissue preservation with low-dose aldehydes and antioxidants, study of the effects of retabolil on gastroenteroanastomosis regeneration, and optimisation of ischaemic damage prevention with low-dose aldehydes. In solving these problems, multifactor economical plans were initially applied to identify the optimal variants for several outputs. Second-order plans were further employed to specify the optimal regimes and construct models describing the optimum region. Recommendations on the choice of the most rational and time-saving regimes have been elaborated.

[Choice of the optimal regimens for preserving the heart with weak aldehyde solutions using mathematical methods of experimental design]. / Vybor optimal'nykh rezhimov konservirovaniia serdtsa slabymi rastvorami al'degidov s ispol'zovaniem matematicheskikh metodov planirovaniia éksperimenta.

An optimal variant of myocardial conservation was found by means of the methods of experimental design with the use of a small number of experiments. This variant consists of different regimens and conditions affecting the results of transplantation with the use of weak aldehyde concentrations. The conservation regimens in question allow more complete protection of the test organ against long-term ischemic injuries preserving myocardial contractility during the post-transplantation period.

[Conditions of yeast freeze-drying studied by methods of planning experiments]. / Izuchenie uslovii liofilizatsii drozhzhei s primeneniem metodov planirovaniia éksperimenta

The effect of seven factors on survival and residual humidity of yeast suspensions was studied during freeze-drying of Saccharomyces cerevisiae using methods of mathematical planning of the experiment. A multifactor experiment of the type 2(7-4) was realized, according to which all factors were varied at two levels. Adequate equations for regression were obtained to describe the process in the temperature zone above the eutectic point (from -10 to -15 degrees C) and below it (from -30 to -40 degrees C). The effect of the studied factors was found to depend on temperature of freeze-drying. The equations were used for optimizing freeze-drying by the method of "sharp ascending".