[The influence of bile on the survival of leukocyte in patients with purulent cholangitis]. / Vliianie zhelchi na vyzhivaemost' leikotsitov u bol'nykh s gnoinym kholangitom.

It was established that while incubation of the blood leucocytes of a healthy person with duodenal bile of a patient, suffering chronical purulent cholangitis, the leucocytes life span enhances. In a patient's bile the leucocytes survival is higher than in healthy person's.

[Humoral link of autoimmune reactions to neuron-specific enolase in post-radiation encephalopathy patients]. / Doslidzhennia humoral'noï lanki autoimunnykh reaktsii do neirospetsyfichnoï ienolazy u khvorykh na postradiatsiinu entsefalopatiiu.

The purpose of this research was to study the humoral link of autoimmune response to the brain antigen i.e. neurospecific enolase (NSE) in liquidators of the Chernobyl accident aftereffects diagnosed as having "postradiation encephalopathy" (PREP). Determined in the PREP patients' serum were: NSE content, level of autoantibodies to NSE, concentration and size of the immune complexes (IC) as well as NSE content in the IC. The majority of PREP patients revealed high serum level of NSE and high level of autoantibodies to NSE. Concentration of small and middle-size IC was 2-3 times higher than normal. So the presence of circulating NSE and autoantibodies thereto in the liquidators' blood serum evidences of an organic lesion of the brain neurons, this causing the development of neurological syndromes. It is likely that at certain stages of the PREP pathogenesis there appear autoimmune responses to neuroantigens which prove the destructive effects of radiation on the CNS. Probably, in patients with PREP 2-3 degrees the autoimmune processes become chronic due to pathogenic action of free autoantibodies to NSE and of small NSE-anti-NSE complexes which are known to be the most pathogenic and capable of being fixed on complementary brain structures promoting their damage.

[The level of embryonic antigens in the blood serum and cerebrospinal fluid of neuro-oncological patients]. / Soderzhanie émbrional'nykh antigenov v syvorotke krovi i likvore neiroonkologicheskikh bol'nykh.

The levels of embryonic antigens (cancer embryonic antigen, alpha-fetoprotein, beta-chorionic gonadotropin were measured in the serum, spinal fluid, the cystic fluid of tumor 83 of neuro-oncological patients. It was found that the blood concentrations of cancer embryonic antigen and alpha-fetoprotein were not generally related to the degree of malignancy and the blood level of beta-chorionic gonadotropin decreased with the higher degree of tumor anaplasia. The high content of beta-chorionic gonadotropin in the spinal fluid suggests its origin from a brain tumor. The fatal postoperative outcome was noted in patients having high preoperative serum levels of alpha-fetoprotein and cancer embryonic antigen with simultaneous much higher concentrations of alpha-fetoprotein in the serum than those in the spinal fluid.

[The effect of a suspension of brain cells from mice of varying age on the growth of tumors, transplanted under the capsule]. / Vliianie suspenzii kletok golovnogo mozga myshei razlichnogo vozrasta na rost opukholei, transplantirovannykh pod kapsulu.

Antitumour activity of cerebral cells at different stages of ontogenesis (embryonic, new-born, adult) has been studied. Researches have been carried out at killer-activity patterns in vitro with target-cells and tumour transplantation under mice kidney's capsule in vivo. It has been established that mice cerebral cells' suspension can decrease the tumour transplants' growth under kidney's capsule. Antiproliferative activity of embryonic and new-born mice cerebral cells was much higher than adult one. The kidney and liver new-born mice cells had no antiproliferative activity at all.

[Clinico-diagnostic value of the immunologic parameters of blood and cerebrospinal fluid in patients with a tumor of the posterior cranial fossa]. / Kliniko-diagnosticheskoe znachenie immunologicheskikh pokazatelei krovi i spinnomozgovoi zhidkosti u bolnykh s opukholíu zadnei cherepnoi iamki.

In 37 patients with a tumor of the posterior cranial fossa, the immunologic indices of the spinal fluid, blood serum and tumor contents were studied. It was established that changes in the immunologic indices (intrathecal synthesis of IgG and IgA, production of the immunoregulatory factors of cellular immunity, severity of lesion of the brain structures) depended on a degree of tumor anaplasia and age of the patients. These findings can be used for diagnosis of cerebral neoplasms of different degree of malignancy with regard for the age of a patient.

[Changes in the immune status of patients with brain tumors in the pre- and postoperative periods]. / Izmeneniia immunnogo statusa u bol'nykh s opukholiami golovnogo mozga v do- i posleoperatsionnom periode.

Changes of the immune status in patients with glioblastomas and meningiomas during the stages of surgical treatment were studied. Functional activity of lymphocytes suffers to a greater measure in patients in the preoperative period and the ratio of the lymphocyte T- and B-subpopulations changes. Preoperative management including hormonal therapy causes further inhibition of the immune status but has no effect on the degree of neurosensitization of the patients, which may be a risk factor of the development of postoperative complications of infectious-inflammatory neuroallergic etiology. Immunogenesis remains inhibited in the early postoperative period, on the 2nd-3rd day after the operation. By the 7th-10th postoperative day significant restoration of the number and functional activity of lymphocytes is encountered in patients with meningiomas, while in patients with glioblastomas inhibition of lymphocyte proliferative activity persists.

[The use of myelopid in the combined treatment of infectious-inflammatory complications in the postoperative period in neuro-oncology patients]. / Primenenie mielopida v kompleksnom lechenii infektsionno-vospalitel'nykh oslozhnenii v posleoperatsionnom periode u neiroonkologicheskikh bol'nykh.

Clinical observations over 48 neurosurgical patients with infectious inflammatory complications and study of their immune status showed that a course of immunocorrective therapy with myelopid produces a favourable clinical effect and normalizes the patient's immune status. Myelopid causes the best normalizing effect in patients with nontumorous pathology of the central nervous system and in extracerebral neoplasms.

[Lymphocyte subpopulations and their functional activity in patients with brain tumors]. / Subpopuliatsii limfotsitov i ikh funktsional'naia aktivnost' u bol'nykh s opukholiami golovnogo mozga.

The authors studied a complex of immunological indices in 69 patients with brain tumours in the pre- and postoperative period. It is shown that in patients with benign brain tumours, preoperative care and surgical intervention largely alter the functional activity of T and B-lymphocytes while patients with malignant tumours of the brain revealed less pronounced changes of quantitative indices of definite subpopulations of lymphocytes against the background of marked reduction of their functional activity. The necessity is emphasized of complex evaluation of immunological indices in patients with brain tumours.

[The modification of the catalytic activity of mitochondrial monoaminoxidase and the suppression of the growth of experimental brain tumors]. / Modifikatsiia kataliticheskoi aktivnosti mitokhondrial'noi monoaminoksidazy i ugnetenie rosta éksperimental'nykh opukholei golovnogo mozga.

A derivative of pyrazinocarbazole the antidepressant pyrazidol, whose inhibition of serotonin deaminase activity of the brain mitochondrial monoamine oxidase is attended by induction of the property of catalysing histamine oxidation, inhibits the growth of glial tumors in experiments. Another derivative of pyrazinocarbazole, which inhibits serotonin deamination but does not induce the appearance of histamine deaminase activity, produces no effect on the growth of glial tumors of the brain.

[The effect of surgical intervention on the state of the immune system in brain tumors]. / Vliianie khirurgicheskogo vmeshatel'stva na sostoianie sistemy immuniteta pri opukholiakh golovnogo mozga.

In patients with benign and malignant brain tumors before the operation, the suppression of the immune system, in particular, proliferative response of lymphocytes to T- and B-mitogens was established. Preoperative preparation of the patients aggravated this process. At day 8-10 after the operation, normalization of the main indices of immunity in patients with benign tumors was noted. In malignant tumors after the operation, the increase in the contents of T- and B-lymphocytes against the background of decrease in their proliferative activity was observed.

[Correction of immunity disorder developing after craniocerebral trauma]. / Korrektsiia narushenii immuniteta, voznikaiushchikh posle cherepno-mozgovoi travmy.

The article presents some data concerning influence of humoral factor received from blood serum of injured animals on humoral and cell immune response of animals. The results show that administration of humoral factor prevents stress-induced devastation of thymus, improves humoral immune response to antigen test (sheep erythrocytes) and restores hypersensitivity of decelerated type (HDT) reactions. Immune stimulating effects are observed both right after cranial trauma and some time later -- 5-7 days after the injury.

[Humoral and cellular immunity in patients with left- and right-sided intracerebral tumors]. / Gumoral'nyi i kletochnyi immunitet u bol'nykh s levo- i pravostoronnimi vnutrimozgovymi opukholiami.

The authors compared the values of the immune status of patients with glial brain tumor of grade III-IV anaplasia in the left and right side in the preoperative period. In patients with the tumor in the right hemisphere, in the frontotemporal region in particular, the absolute number of rosette-forming cells in peripheral blood and the blast-transformation activity of lymphocytes in response to phytohemagglutinin were reduced significantly (p less than 0.05) as compared to the values in patients with the tumor on the left side. The number of B-lymphocytes and the blood immunoglobulin level were not changed. The possible mechanisms of the revealed differences are discussed with due account of data on immunogenesis regulation by the left hemisphere.

[Immunologic status of patients in the late period after cranio-cerebral trauma]. / Immunnyi status u bo'lnykh v otdalennom periode cherepno-mozgovoi travmy.

Immune disorders characteristic of the late period of craniocerebral trauma involve T-cellular, regulatory link and were represented by a reduction of T-cells count and function with disbalance in lymphocytes-helpers, increase in macrophagal and lymphoid suppressors activity susceptible to indomethacin++. The changes also include the neurosensibilization of cellular and humoral type to brain-specific++ proteins: OBM, 14-3-2, S-100. Most pronounced changes were detected in patients after severe brain concussion with focal neural changes persisting in the late period.