ABSTRACT
PURPOSE: This randomized, open-label, parallel-group, multicenter study was designed to compare the efficacy and safety of bendamustine and chlorambucil in previously untreated patients with advanced (Binet stage B or C) chronic lymphocytic leukemia (CLL). PATIENTS AND METHODS: Patients (Subject(s)
Chlorambucil/therapeutic use
, Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy
, Nitrogen Mustard Compounds/therapeutic use
, Adult
, Aged
, Antineoplastic Agents/adverse effects
, Antineoplastic Agents/therapeutic use
, Bendamustine Hydrochloride
, Chlorambucil/adverse effects
, Disease-Free Survival
, Female
, Fever/chemically induced
, Follow-Up Studies
, Humans
, Male
, Middle Aged
, Nausea/chemically induced
, Neutropenia/chemically induced
, Nitrogen Mustard Compounds/adverse effects
, Thrombocytopenia/chemically induced
, Time Factors
, Treatment Outcome