ABSTRACT
Authors have studied the effect of antistax on the cerebral venous discirculation (VD) in patients with discirculatory encephalopathy. Forty-three patients (mean age 46,8±1,8 years) received antistax in daily dose 720 mg during 2 months. Efficacy of treatment was assessed using the Visual Analogous Scale, Doppler ultrasound data, result of a non-invasive study of peripheral arterial tonus (PAT). After the completion of treatment course, the significant decrease of complaints, intensity of VD by the ultrasound data and parameters of arterial hardness by PAT data was observed. The excellent tolerability was reported by 61,1% patients; good one - by 38,9%. The results confirm the possibility of using antistax in neurological practice for treatment cerebral VD.
Subject(s)
Brain/blood supply , Cerebrovascular Disorders/drug therapy , Quercetin/analogs & derivatives , Venous Insufficiency/drug therapy , Cerebrovascular Disorders/etiology , Endothelium, Vascular/drug effects , Female , Humans , Male , Middle Aged , Quercetin/therapeutic use , Treatment Outcome , Venous Insufficiency/complicationsABSTRACT
The effectiveness of treatment of anxiety-depressive syndrome with cymbalta, the selective inhibitor of serotonin and noradrenalin reuptake, has been assessed in 35 patients with discirculatory encephalopathy (mean age 50.9+/-1.78 years). Patients received cymbalta in dosage 60 mg daily during 2 months. Therapeutic efficacy was analyzed with a complaint questionnaire, depression scales (CES-D, Beck, Zung), the Spielberger's anxiety scale in the modification of Khanin, the Luescher color test and a battery of tests for assessment of cognitive processes. The statistically significant decrease of complaint frequency, intensity of depression, regardless of its baseline severity, and anxiety level was observed to the end of treatment course. The cognitive tests revealed the marked improvement of sustained attention functions and related with them short-term and working memory. Tolerability of the drug was rated as excellent, good and fair was reported by 90.6% of patients and 91.9% of physicians. The drug may be considered safety and effective for basic pharmacotherapy of affective and concomitant cognitive disorders of vascular genesis.
Subject(s)
Antidepressive Agents/therapeutic use , Anxiety Disorders/drug therapy , Brain Ischemia/complications , Depressive Disorder/diet therapy , Selective Serotonin Reuptake Inhibitors/therapeutic use , Thiophenes/therapeutic use , Adult , Aged , Anxiety Disorders/etiology , Depressive Disorder/etiology , Duloxetine Hydrochloride , Female , Humans , Male , Middle Aged , Psychological Tests , Syndrome , Treatment OutcomeABSTRACT
80 liquidators of Chernobyl disaster with aggravation of duodenal ulcer were examined, as well as a control group of 70 patients. In the group of liquidators some characteristic features were disclosed, namely peculiarities in the state of abdominal mucosa and clinical course of the disease. These data were obtained in the results of hematological, immunological and biochemical researches.
