ABSTRACT
AIM: To characterize the clinical and laboratory manifestations in patients with HG viral infection frequently concurrent with chronic HCV infection and the potentialities of their treatment. MATERIALS AND METHODS: 109 patients with suspected chronic hepatic disease were examined. The markers of HGV, HCV, HBV, and TTV infections were determined. The possible factors of infection, biochemical parameters, and the efficiency of antiviral therapy were assessed. RESULTS: Hepatitis G virus RNK was detected in 32 cases, a combined variant of hepatitis G + C viruses RNA was found in 77 patients with chronic viral hepatitis (CVH). Among the presumed routes of contamination in the mixed variant of CVH, there were most common intravenous injection of narcotic drugs; in monoinfection (HGV), there were parenteral interventions in medical facilities and blood transfusion. Antiviral treatment of 13 patients with chronic HGV + HCV infection yielded a positive result in 5 patients after 3-month therapy. CONCLUSION: In patients with CVH, HG virus infection was more frequently observed in combination with CVHC, less frequently as monoinfection. In HG virus monoinfection, biochemical studies revealed the enhanced activity of transaminases and hyperbilirubinemia that was absent in the mixed variant of HGV + HCV. The financial capacities of patients should be taken into account while choosing therapy.
Subject(s)
Antiviral Agents/therapeutic use , Flaviviridae Infections , GB virus C/isolation & purification , Hepatitis, Viral, Human , Adult , Female , Flaviviridae Infections/drug therapy , Flaviviridae Infections/etiology , Flaviviridae Infections/virology , GB virus C/drug effects , Hepatitis C/drug therapy , Hepatitis C/etiology , Hepatitis C/virology , Hepatitis, Viral, Human/drug therapy , Hepatitis, Viral, Human/etiology , Hepatitis, Viral, Human/virology , Humans , Male , Treatment OutcomeABSTRACT
Clinical patterns of tuberculous meningitis have been analyzed for 32 admissions to the bacterial meningitis department of the 2nd Moscow Infection Hospital in 1983-1991. Early diagnosis of tuberculous meningitis caused great difficulties because of rare cases of tuberculous history, atypical symptoms (an acute onset, in particular), an obscure meningeal syndrome, rare neurological symptoms, atypical liquor characteristics (frequent neutrophil pleocytosis, a small protein rise, normal glucose). Secondary bacterial meningitides presented most serious difficulties for differential diagnosis. So did cerebral abscesses and viral meningitis. Antituberculous therapy should be started at first sings of tuberculous nature of meningitis as the disease outcomes are determined to a large extent by early administration of proper treatment.
Subject(s)
Tuberculosis, Meningeal/diagnosis , Adolescent , Adult , Diagnosis, Differential , Diagnostic Errors , Fatal Outcome , Female , Humans , Male , Middle Aged , Time Factors , Tuberculosis, Meningeal/cerebrospinal fluidSubject(s)
Meningitis/etiology , Meningocele/complications , Rectal Fistula/complications , Adult , Female , Humans , Recurrence , Sacrococcygeal RegionSubject(s)
Blood-Brain Barrier/physiology , Meningitis, Meningococcal/metabolism , Meningitis, Pneumococcal/metabolism , Nerve Tissue Proteins/analysis , Acute Disease , Adolescent , Adult , Aged , Aged, 80 and over , Alpha-Globulins/analysis , Antigens/analysis , Brain/immunology , Epitopes/analysis , Female , Humans , Male , Middle AgedSubject(s)
Brain Abscess/diagnosis , Communicable Diseases , Hospitals, Special , Adolescent , Adult , Brain Abscess/etiology , Diagnosis, Differential , Female , Humans , Male , Methods , Middle Aged , MoscowABSTRACT
Altogether 20 patients with purulent meningitis caused by agents of rare species were observed. Difficulties in etiological diagnosis and the severity of a clinical course were noted. In most cases this disease developed in persons with associated diseases. In a lingering course of the disease repeated bacteriological investigations of blood and liquor, and serological investigations are recommended.
