ABSTRACT
White mice were exposed to hypoxic hypoxia during 30 days. In the study a correlation between the altitude ceiling and various physiological parameters (body weight, body temperature variations in response to a cold stress (5 degrees C), hemoglobin content, coefficients of adaptive oxygen consumption determined as the ratio of oxygen consumption at 6000 m to that at sea level (K1) and the ratio of oxygen consumption in hypoxic environment to that in a normoxic atmosphere (K2) was established. The data obtained allow the conclusion that the multiple regression method can be used for measuring objectively the tension of regulatory systems and for discriminating stages of animal adaptation to hypoxic hypoxia.
Subject(s)
Altitude , Atmospheric Pressure , Hypoxia/physiopathology , Adaptation, Physiological , Animals , Atmosphere Exposure Chambers , Body Temperature , Body Weight , Cold Temperature , Hemoglobins/analysis , Male , Mice , Oxygen Consumption , Regression AnalysisSubject(s)
Oils/toxicity , Animals , Drug Combinations , Environmental Exposure , Male , Mice , Oxidation-Reduction , Safety , Time Factors , VolatilizationSubject(s)
Air , Carbon Monoxide/toxicity , Gases/toxicity , Animals , Drug Combinations , Drug Synergism , Environmental Exposure , Male , Mice , Time FactorsABSTRACT
The experiments on white male mice have shown that the combined effect of different concentrations of mixtures of volatile products of thermooxidative decomposition of the lubricating oil 36/IKUA and hypoxia at altitudes 5,000; 7,000 and 8,000 m depends on the intensity of the combined factors. It is indicated that maximally allowable concentrations of the above mixtures in the space cabin atmosphere should be determined, taking into consideration the level of hypoxia.
Subject(s)
Hypoxia/metabolism , Oils, Volatile/pharmacology , Altitude , Animals , Atmospheric Pressure , Dose-Response Relationship, Drug , Drug Combinations , Lubrication , Mice , Time Factors , VacuumSubject(s)
Adipates/pharmacology , Cresols/pharmacology , Skin Absorption/drug effects , Tritolyl Phosphates/pharmacology , Animals , Drug Combinations , Esters , Guinea Pigs , Male , Mice , Time FactorsABSTRACT
The experiments carried out on white male rats have shown no significant changes in the animals that may have resulted from their 30-day consumption of reclaimed water which contained up to 34 mg/l methanol and was produced by sorption purification of the atmospheric condensate during a prolonged manned experiment.
