ABSTRACT
A series of phenylbutene and butanol derivatives (6a-j, 12, 13, 15, 17, 24b,c, 26, 27a,b) were prepared from the readily available resorcinol derivatives 2a-f and 7-hydroxy-chroman (18). The products were tested for inhibitory activity on the LPS-induced TNF-alpha production in the plasma in comparison with that of cabenegrin A-I (1a).
Subject(s)
Benzene Derivatives/chemical synthesis , Benzopyrans/chemical synthesis , Benzopyrans/pharmacology , Butanols/chemical synthesis , Lipopolysaccharides/antagonists & inhibitors , Tumor Necrosis Factor-alpha/biosynthesis , Animals , Benzene Derivatives/chemistry , Benzene Derivatives/pharmacology , Benzopyrans/chemistry , Butanols/chemistry , Butanols/pharmacology , Male , Mice , Mice, Inbred BALB C , Structure-Activity RelationshipABSTRACT
For pharmacological investigation various types of silybin analogues have been synthesized. According to the results of preliminary tests, many of the prepared benzodioxane analogues of chalcones, chalcone epoxides, isoflavones, flavanones and aurones possessed hypolipidemic activity.
Subject(s)
Flavonoids/chemical synthesis , Hypolipidemic Agents/chemical synthesis , Silymarin/chemical synthesis , Chemical Phenomena , Chemistry , Chemistry, Physical , Magnetic Resonance Spectroscopy , Silymarin/analogs & derivativesABSTRACT
3-Acylamino-, -arylsulfonylamino-, -(N'-arylureido)-, -arylideneamino- and -arylcarbamoyl-4-hydroxycoumarins have been synthesized and tested for antibacterial and antifungal activity. 3-Arylcarbamoyl-4-hydroxycoumarins have been shown to possess significant activity against Gram-positive bacteria; 3-acylamino-4-hydroxycoumarins have moderate antibacterial and antifungal effects whereas the additional compounds are inactive.
