[Carcinogenic hazard of chloroform and other drinking water chlorination by-products].

The paper presents the results of studying the carcinogenic effect of chloroform and its combination with carbon tetrachloride, 1,2-dichloroethane, trichloroethylene during chronic oral administration to F1(CBAxC57Bl6) mice. There is a relationship between the manifestation of carcinogenesis to the dose of chloroform and a combination of chemicals, as well as its enhancement upon exposure to the combination as compared with acute administration of chloroform. Exposure to a combination of substances at the level of their maximum permissible concentrations does not affect carcinogenesis. The possible mechanisms of the specific features of carcinogenesis in this experiment are discussed.

[Hygienic assessment of the risk of ambient air pollution to human health in the Ukraine's industrial towns].

The paper presents the results of a hygienic analysis of ambient air pollution in 18 industrial cities of the Ukraine in 1990, 1996, and 2003 and the calculations of noncarcinogenic and carcinogenic hazards of ambient air pollutions to human health. According to the calculated complex indices P, the cities were ranked by the magnitude of ambient air pollution (an environmental disaster area; extreme, severe, moderate, weak, and permissible pollution). The non-carcinogenic and (total indices, indices for critical organs and systems) carcinogenic risks were estimated for the populations of the studied cities in relation to the level of atmospheric pollution on their territories. Proposals are given for further development of studies.

[Hygienic assessment of the hazard of ambient air carcinogenic factors].

The paper shows an extremely greater danger of aerogenic doses of carcinogenic substances entering with smoking products than that of an aerogenic load in the industrial centers. The individual and population risks of cancer due to smoking of the Ukraine's common cigarettes and the economic damage caused by the treatment of this number of patients to the country have been calculated. For a full assessment of the carcinogenic risk of tobacco smoke, it is necessary to determine all its carcinogenic constituents, their precursors, and possible transformation groups at high temperatures.

[Hygienic evaluation of ambient air pollution in the industrial towns of the Ukraine and assessment of its risk to human health].

The paper presents the results of a hygienic analysis of ambient air pollution in 18 large industrial towns of the Ukraine in 1990, 1996, and 2003 and calculations of cancer and non-cancer risks of atmospheric pollutions to the population's health. It also provides proposals for further development of studies.

[Comparative assessment of the cancer risk of the products of smoking and ambient air pollution].

Danger from aerogenic dose carcinogens entering the body with smoking products is shown to be essentially greater than that from aerogenic loading in industrial centers. The individual and population risks for smoking-induced cancer and the economic damage to the country, associated with the treatment of a large number of patients are given. To make a complete assessment of the carcinogenic risk of tobacco smoking, it is necessary to estimate all its carcinogenic constituents, their precursors, and possible transformation products at elevated temperatures.

[Oncologic hygienic aspects of regulation of benz(a)pyrene in food products]. / Onkogigienicheskie aspekty reglamentirovaniia benz(a)pirena v produktakh pitaniia.

The paper presents a methodological scheme for regulating the acceptable levels of benz(a)pyrene in the foodstuffs is presented. It also gives a list of the acceptable levels of this carcinogen in the foodstuffs whose specific values depend on its daily dosage and the pattern of a standard diet for the Ukraine's population.

[Hygienic aspects of the study of the synthesis of nitrosamines from their precursors]. / Gigienicheskie aspekty izucheniia sinteza nitrozaminov iz ikh predshestvennikov.

The paper presents data on the content of nitrosamines (NA), such an nitrosodimethylamine, nitrosodiethylamine, and their precursors (NO2 and amines) in the ambient air of different functional zones of a city. A high correlation between NA and NO2 in the air was established. NO2 was shown to have the leading role as a nitrosating agent in the model system and air during exogenous synthesis. The findings support the possible endogenous production and the role of NO2 in this process.

[Content of carcinogenic substances in the oil-refrigerating technology]. / Soderzhanie kantserogennykh veshchestv v smazochno-okhlazhdaiushchikh tekhnologicheskikh sredakh.

Benz(a)pyrene and nitrosamines serve as bases for oiling refrigerating technologic mediums. Such mediums applied to metals processing lead to higher carcinogens content and their release into the air of working area. Studies demonstrate that employees are exposed to effective doses of carcinogens.

[Experimental substantiation of MPEL of dibenz(a,n)anthracene in atmospheric air]. / Eksperimental'noe obosnovanie PDK dibenz(a,n)antratsenav atmosfernom vozdukhe.

Overt dependence of lung tumour development on the values of the dose administered was shown in experiments on inbred white rats under intratracheal administration of various doses of dibenz (a, h) anthracene (DBA); minimal-effect dose and maximal no-effect dose of DBA were established in the experiment. A theoretically calculated allowable dose was used to calculate MAC of the chemical under study for the ambient air 5 ng/m3 was recommended as an average 24-hour maximum allowable concentration of DBA in ambient air.