Effects of Cichorium Intybus L. Root Extract on Secretory Activity of the Stomach in Health and Ulcer Disease.

Gastroprotective effect of Cichorium intybus L. root extract is demonstrated on H. Shay's model of experimental ulcer in rats. The effect is attributed to the antisecretory activity of the plant and stimulation of defense barrier function of the gastric mucosa. The regulatory effect of the phytocomplex on seasonal characteristics of the gastric secretory and defense functions in dogs with Basov's fistula is detected.

[Effect of natural nootropic and adaptogen preparations on the cortex bioelectrical activity in rats]. / Vliianie prirodnykh preparatov s nootropnymi i adaptogennymi svoistvami na bioélektricheskuiu aktivnost' kory mozga krys.

The influence of new nootrope and adaptogen preparations representing dry extracts from Scutellaria baicalensis (Georgi), Bergenia crassifolia (Fritsch), and velvet antlers of Siberian deer (Cervus elaphus sibiricus) on the bioelectric activity (cortex Fourier spectral EEG power) under conflict situation and conditioned reflex development was studied in rats. In both tests, the drugs produced similar changes in the EEG activity: (i) increase in the partial contribution of delta-activity and general spectral power, (ii) depression in the alpha and beta 1-rhythm power, (iii) depression of theta-activity in some cases. The EEG activity changes depended on the initial state and were closely connected with the behavior of the test animals. The drug administration led to normalization of the alpha and beta 1 activity correlated with the improved behavioral characteristics. At the same time, the delta activity was virtually not affected and lost the correlation with behavior.

[Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patents with lung cancer]. / Ekstrakt shlemnika baikal'skogo sukhoi v kachestve gemostimuliatora v usloviakh protivoopukholevoi khimioterapii bol'nykh rakom legkogo.

Hemopoiesis was studied in 88 patients with lung cancer during antitumor chemotherapy and its combination with a dry SB extract. Administration of the plant preparation was accompanied with hemopoiesis stimulation, intensification of bone-marrow erythro- and granulocytopoiesis and increase in the content of circulating precursors of the type of erythroid and granulomonocytic colony-forming units.

[Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy]. / Vliianie ékstracta shlemnika baikal'skogo na immunologicheskii status bol'nykh rakom legkogo v usloviiakh protivoopukholevoi khimioterapii.

Cytostatic therapy of patients with lung cancer is attended with decrease in the relative number of T-lymphocytes and their theophylline-resistant population. Patients who were given SB showed a tendency towards increase of these parameters during antitumor chemotherapy. The immunoregulation index (IRI) in this case was approximately twice the background values during the whole period of investigation. The inclusion of SB in the therapeutic complex promotes increase in the number of immunoglobulins A at a stable level of immunoglobulins G.

[The blood-stimulating properties of lysine baicalinate]. / Gemostimuliruiushchie svoistva baikalinat-lizina.

The possibility of stimulating hemopoiesis inhibited by a single dose (2.0 Gr) of total irradiation with Lysini Baicalinatum, a vegetable origin drug, has been studied on CBA mice. A 3-fold drug administration (total dose 150 mg/kg) on days 3, 4, and 5 after irradiation promoted bone marrow erythropoiesis and less granulopoiesis. A mechanism of Lysini Baicalinatum stimulating effect is connected with intensification of hemopoiesis inducing microenvironment's functional activity.

[The principles for creating drug preparations of natural origin that stimulate hematopoiesis]. / Printsipy sozdaniia lekarstvennykh preparatov--stimuliatorov krovetvoreniia prirodnogo proiskhozhdeniia.

The paper outlines the principles in designing hemostimulators by using glycosamineglycans. Hemostimulating properties of the tested agents is likely to be primarily due to the presence of D-glucuronic acid in their structure. The homotypic mechanisms are largely responsible for all agents' effect in stimulating hemopoiesis. Thus, they all virtually activate the function of the hemopoiesis-inducing microenvironment. In addition, they directly or indirectly stimulate the processes of proliferation and differentiation of precursor cells of erythro- and granulomonocytopoiesis.

High-performance liquid chromatographic method for the determination of mangiferin, likviritin and dihydroquercetin in rat plasma and urine.

The use of reversed-phase high-performance liquid chromatography for the determination of the biologically active plant phenolic compounds mangiferin, likviritin and dihydroquercetin is described. Perchloric acid (35%) was used for deproteinization in the case of mangiferin and likviritin, and acidified methanol for dihydroquercetin. Detection was performed at 254, 275 and 290 nm for mangiferin, likviritin and dihydroquercetin in plasma, and 365, 312 and 290 nm in urine, respectively. The limit of detection was 0.2 micrograms/ml for plasma and 0.5 micrograms/ml for urine.

[2 organizational forms of facilities for mentally ill patients who lost their family care]. / O dvukh organizatsionnykh formakh zashchishchennogo zhi'lia dlia psikhicheski bo'lnykh, utrativshikh rodstvennye sviazi.

The peculiarities of rehabilitation were studied in patients with long-lasting mental diseases who had lost their housing and relatives confined to specialized clinic-hotel or "halfway"-type units. The efficiency of these types of secure housing providing high level of therapeutic environment is stressed. The housing conditions and interrelations between the described forms are discussed.

[Use of conditioned reflex therapy combined with teturam administration in chronic alcoholism]. / Primenenie uslovnoreflektornoi terapii v sochetanii s priemom teturama pri khronicheskom alkogolizme.

In order to treat patients who are resistant to antialcohol therapy (110 patients), the authors used sensibilizing therapy throughout the entire course of treatment in conjunction with reflex therapy conducted by using conditional drops (1/20 part of a gulp) of alcohol. This method is technically simple, causes no complications and produces more persistent remissions, e.g. remissions lasting over one year were observed in almost half of the patients (47,2%).