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1.
Probl Radiac Med Radiobiol ; 26: 437-448, 2021 Dec.
Article in English, Ukrainian | MEDLINE | ID: mdl-34965565

ABSTRACT

OBJECTIVE: to evaluate the parameters of inflammatory reaction and oxidative stress in patients with non-alcoholicfatty liver disease (NAFLD) in the remote period after the influence of the Chornobyl accident factors. MATERIALS AND METHODS: Eighty two patients with NAFLD who had been exposed to ionizing radiation as a result ofthe Chornobyl accident and have concomitant cardiovascular pathology were examined. Hematological parametersand the level of highly sensitive C-reactive protein (hsCRP) were determined, and the content of products of oxida-tive modification of lipids and proteins was evaluated. RESULTS: Activation of the processes of oxidative modification of lipids and proteins was observed in most patientswith NAFLD. According to the level of hsCRP, the presence of subclinical inflammation and the risk of developingcomplicated cardiovascular pathology was found in 58 % of patients with NAFLD. The neutrophil / lymphocyte ratiocorrelates positively with hsCRP and can be used as an available routine clinical marker for selection among patientswith NAFLD persons with increased risk of cardiovascular complications. CONCLUSIONS: HsCRP, oxidative modification products of lipids and proteins, ESR, and leukograms should be used toassess the degree of systemic inflammation in people affected by the Chornobyl accident, suffering NAFLD with con-comitant cardiovascular disease.


Subject(s)
Cardiovascular Diseases/physiopathology , Chernobyl Nuclear Accident , Inflammation/physiopathology , Non-alcoholic Fatty Liver Disease/physiopathology , Radiation Exposure/adverse effects , Radiation Injuries/physiopathology , Radiation, Ionizing , Aged , Cardiovascular Diseases/etiology , Emergency Responders/statistics & numerical data , Humans , Inflammation/epidemiology , Inflammation/etiology , Male , Middle Aged , Non-alcoholic Fatty Liver Disease/epidemiology , Radiation Dosage , Radiation Injuries/epidemiology , Radiation Injuries/etiology , Radioactive Hazard Release , Risk Assessment/statistics & numerical data , Ukraine/epidemiology
2.
Exp Oncol ; 42(4): 310-313, 2020 12.
Article in English | MEDLINE | ID: mdl-33355875

ABSTRACT

AIM: To study the features of the bronchial mucosa lesion in relation to centrally growing lung cancer (LC) according to diagnostic fibrobronchoscopy in comparison with the results of cytomorphological data to determine the possible origin of tumor growth (histogenesis). PATIENTS AND METHODS: The data of fibrobronchoscopy and cytological findings based on the materials of 75 patients with a clinical diagnosis of LC were studied and compared. By the sum of the numerous cytomorphological features of epithelial cells and their components, the cells of the cylindrical epithelium and LC of various histological types were identified. The cells in bronchial smears and bronchial lavage were stained by Pappenheim and Papanicolau. Diagnostic material was examined by light microscopy. RESULTS: We have found that in a part of the patients (49%), the tumors with exophytic growth in the bronchus are covered with a cylindrical epithelium, which indirectly indicates the origin of cancer growth under the epithelial layer. In cytological preparations of 51% patients, cancer cells were found, which confirms the tumor invasion into the bronchial mucosa. In 48 (64%) patients, fibrobronchoscopy revealed that the examined bronchus was compressed from 50% to pinpoint width, evidencing that tumor growth develops from the outside, peribronchially. CONCLUSION: The obtained data indirectly confirm the development of central LC from type II pneumocytes, which are found in the glands of the submucous membrane of the bronchus. However, it does not exlude the development of this type of LC from the basal cell of the bronchial epithelium.


Subject(s)
Bronchi/pathology , Lung Neoplasms/etiology , Lung Neoplasms/pathology , Biomarkers , Biopsy , Bronchi/metabolism , Bronchoscopes , Disease Susceptibility , Histocytochemistry/methods , Humans , Immunohistochemistry/methods , Lung Neoplasms/diagnostic imaging , Respiratory Mucosa/metabolism , Respiratory Mucosa/pathology
3.
Probl Radiac Med Radiobiol ; 19: 334-44, 2014 Sep.
Article in English, Ukrainian | MEDLINE | ID: mdl-25536570

ABSTRACT

Objective. An evaluation of the changes in nitric oxide system by the level of its stable metabolites in the blood serum and their comparison with content of 137Сs in the body of children-residents of radioactively contaminated territories. Materials and methods. The children of school age, the residents of radioactively contaminated territories were examined. The levels of nitrogen compounds (NO2- and NO3-) were determined by the standard method using Grissreagent. 137Сs content was determined in the children body by whole-radioactive body counter. Results. Studies of nitric oxide metabolite content in the blood serum revealed the decrease in nitrite level under an absence of the significant changes in nitrate content and sum of NO metabolites in the children-residents of radioactively contaminated territories. An increase in 137Cs content in the body was accompanied by a decrease of nitrite level in the blood serum of a significant part of children.

4.
Lik Sprava ; (5): 3-8, 2013.
Article in Russian | MEDLINE | ID: mdl-24605624

ABSTRACT

The ultrastructure of peripheral blood lymphocytes of children which living in conditions of chronic intake of 137Cs through the food chain studied by method of transmission electron microscopy. The essential changes in the submicroscopic organization of intracellular organelles, especially mitochondria, in the basic group compared to control. The most pronounced changes were observed in the subgroup of children with the level of incorporated 137Cs exceeding 6845 Bq.


Subject(s)
Chernobyl Nuclear Accident , Environmental Exposure/analysis , Lymphocytes/ultrastructure , Radioactive Pollutants/blood , Adolescent , Case-Control Studies , Cesium Radioisotopes/blood , Child , Humans , Lymphocytes/radiation effects , Microscopy, Electron, Transmission , Radiation Monitoring , Ukraine
5.
Lik Sprava ; (4): 3-7, 2013 Jun.
Article in Russian | MEDLINE | ID: mdl-25095676

ABSTRACT

We applied scanning electron microscope to study of surface architectonics of erythrocytes and lymphocytes peripheral blood in children born after the Chernobyl accident and living in conditions of chronic incorporation 137Cs. We found significant changes in surface structure membranes of red blood cells and peripheral blood lymphocytes in the basic childrens group compared with control one. The most striking changes were in children with levels incorporated 137Cs from 6845 to 16522 Bq.


Subject(s)
Cell Membrane/radiation effects , Cesium Radioisotopes/adverse effects , Chernobyl Nuclear Accident , Erythrocytes/radiation effects , Leukocytes, Mononuclear/radiation effects , Adolescent , Cell Membrane/ultrastructure , Child , Dose-Response Relationship, Radiation , Erythrocytes/ultrastructure , Female , Humans , Leukocytes, Mononuclear/ultrastructure , Male , Microscopy, Electron , Radiation Dosage , Radiometry
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