1.
Phys Rev B Condens Matter
; 54(12): R8381-R8384, 1996 Sep 15.
Article
in English
| MEDLINE
| ID: mdl-9984600
2.
Bioorg Med Chem
; 4(6): 877-80, 1996 Jun.
Article
in English
| MEDLINE
| ID: mdl-8818237
ABSTRACT
(S)-1-Phenyl-3-buten-1-ol (1), prepared in high optical purity by enzymatic resolution of the racemate, is a convenient building block for the synthesis of (R)-fluoxetine (7a) and (R)-tomoxetine (7b). Compound 1 was converted to the title drugs by etherification with appropriate phenols under Mitsunobu conditions, ozonolysis of the terminal double bond, mesylation of the resulting alcohol and substitution with methylamine.
Subject(s)
Antidepressive Agents/chemical synthesis , Fluoxetine/chemical synthesis , Propylamines/chemical synthesis , Antidepressive Agents/chemistry , Atomoxetine Hydrochloride , Enzymes/chemistry , Fluoxetine/chemistry , Magnetic Resonance Spectroscopy , Propylamines/chemistry , Spectroscopy, Fourier Transform Infrared , Stereoisomerism
3.
Phys Rev B Condens Matter
; 53(8): 4544-4548, 1996 Feb 15.
Article
in English
| MEDLINE
| ID: mdl-9984010
4.
Phys Rev B Condens Matter
; 50(19): 14069-14076, 1994 Nov 15.
Article
in English
| MEDLINE
| ID: mdl-9975623