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AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type.
Chow, Chit; Liu, Angi Y; Chan, Wai S; Lei, Kenny I K; Chan, Wing Y; Lo, Anthony W I.
Haematologica ; 90(2): 274-5, 2005 Feb.
Article in English | MEDLINE | ID: mdl-15710591

ABSTRACT

Phosphorylated AKT has been detected in extranodal NK/T-cell lymphoma, nasal type (ENTL). Either interleukin-2 (IL-2) or interleukin-15 (IL-15) could prevent AKT dephosphorylation and apoptosis in the NK-92 cell line model. IL-15, but not IL-2, was preferentially elevated in patients' serum. AKT and IL-15 may be important in ENTL tumor survival.


Subject(s)
Killer Cells, Natural/cytology , Lymphoma, T-Cell/immunology , Nose Neoplasms/immunology , Proto-Oncogene Proteins c-akt/physiology , Cell Line, Tumor , Cell Survival , Humans , Immunohistochemistry , Immunophenotyping , Interleukin-15/blood , Interleukin-15/metabolism , Interleukin-2/metabolism , Lymphoma/pathology , Lymphoma, T-Cell/enzymology , Nose Neoplasms/enzymology , Phosphorylation , Proto-Oncogene Proteins c-akt/metabolism
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