ABSTRACT
PURPOSE: To investigate the rate of bleb-related endophthalmitis over 5 years in a Chinese population. METHODS.:Retrospective chart review. RESULTS: Of 988 trabeculectomies performed over 5 years, one case (0.1%) developed early endophthalmitis caused by Morganella morganii, which was rarely reported in the literature. Six cases (0.6%) developed late-onset endophthalmitis. Mitomycin C significantly increased the risk of late-onset endophthalmitis (p=0.0002). CONCLUSIONS: Physicians should weigh the benefits against the risks of mitomycin C application in performing trabeculectomies.
Subject(s)
Endophthalmitis/microbiology , Eye Infections, Bacterial/microbiology , Postoperative Complications , Trabeculectomy , Adult , Aged , Alkylating Agents/administration & dosage , Anti-Bacterial Agents/therapeutic use , Asian People/ethnology , China/epidemiology , Drug Therapy, Combination , Endophthalmitis/drug therapy , Endophthalmitis/ethnology , Enterobacteriaceae Infections/drug therapy , Enterobacteriaceae Infections/ethnology , Enterobacteriaceae Infections/microbiology , Eye Infections, Bacterial/drug therapy , Eye Infections, Bacterial/ethnology , Female , Glaucoma/surgery , Humans , Male , Middle Aged , Mitomycin/administration & dosage , Morganella morganii/isolation & purification , Retrospective Studies , Staphylococcal Infections/drug therapy , Staphylococcal Infections/ethnology , Staphylococcal Infections/microbiology , Staphylococcus aureus/isolation & purification , Streptococcal Infections/drug therapy , Streptococcal Infections/ethnology , Streptococcal Infections/microbiology , Viridans Streptococci/isolation & purification , Vitreous Body/microbiologyABSTRACT
AIM: To determine the effect of brimonidine tartrate 0.2% and latanoprost 0.005% on pulsatile ocular blood flow (POBF) in patients with normal tension glaucoma (NTG). METHOD: NTG patients with progressive optic neuropathy, new disc haemorrhage, or field defects that threatened fixation were enrolled into a randomised, investigator masked, crossover study. Group I patients received 4 weeks each of latanoprost, lubricant, and brimonidine, while group II patients received 4 weeks each of brimonidine, lubricant, and latanoprost. Diurnal POBF was measured at baseline and after each 4 week treatment. RESULTS: 25 patients completed the study and had reliable POBF measurement at each visit. There was no significant diurnal change in baseline POBF (p = 0.768). Latanoprost increased POBF by 213 (SD 257) micro l/min (22.8%, p <0.001) while brimonidine increased it by 97 (183) micro l/min (10.4%, p = 0.014). POBF increased at 8 am (p = 0.004), 12 noon (p = 0.002), and 4 pm (p <0.001) with latanoprost, while it increased only at 8 am (p = 0.016) with brimonidine. After adjusting for the factor of IOP, neither latanoprost nor brimonidine increased POBF significantly. CONCLUSIONS: Latanoprost increases the mean POBF that is related to its IOP lowering effect. The increase in POBF noted after brimonidine is within the range of long term variation and may not be attributable to the drug effect.
