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1.
Ann Thorac Surg ; 99(4): 1459-63, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25841842

ABSTRACT

We report a novel T-shaped linear-stapled intrathoracic esophagogastric anastomosis for minimally invasive Ivor Lewis esophagectomy. A unique feature of this technique is a "gastric pouch" that is preserved proximal to the gastric conduit and which serves as the stapler-firing pathway to protect the gastric conduit. The linear stapler is placed through an auxiliary port in the seventh intercostal space on the right posterior axillary line and fired along the longitudinal axis of the thorax, without being constrained by limited intrathoracic space. This technique, which has been performed in 8 patients, is efficient, reliable, and easy to perform.


Subject(s)
Esophageal Neoplasms/surgery , Esophagectomy/methods , Surgical Stapling , Thoracoscopy/methods , Anastomosis, Surgical/methods , Esophageal Neoplasms/pathology , Esophagus/surgery , Humans , Minimally Invasive Surgical Procedures/methods , Stomach/surgery , Treatment Outcome
2.
PLoS One ; 7(5): e37960, 2012.
Article in English | MEDLINE | ID: mdl-22662257

ABSTRACT

Curcumin, the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development. However, little is known about its anti-tumor mechanism in small cell lung cancer (SCLC). In this study, we found that curcumin can inhibit SCLC cell proliferation, cell cycle, migration, invasion and angiogenesis through suppression of the STAT3. SCLC cells were treated with curcumin (15 µmol/L) and the results showed that curcumin was effective in inhibiting STAT3 phosphorylation to downregulate of an array of STAT3 downstream targets ,which contributed to suppression of cell proliferation, loss of colony formation, depression of cell migration and invasion. Curcumin also suppressed the expression of proliferative proteins (Survivin, Bcl-X(L) and Cyclin B1), and invasive proteins (VEGF, MMP-2, MMP-7 and ICAM-1). Knockdown of STAT3 expression by siRNA was able to induce anti-invasive effects in vitro. In contrast, activation of STAT3 upstream of interleukin 6 (IL-6) leads to the increased cell proliferation ,cell survival, angiogenesis, invasion, migration and tumor growth. Our findings illustrate the biologic significance of IL-6/JAK/STAT3 signaling in SCLC progression and provide novel evidence that the pathway may be a new potential target for therapy of SCLC. It was concluded that curcumin is a potent agent in the inhibition of STAT3 with favorable pharmacological activity,and curcumin may have translational potential as an effective cancer therapeutic or preventive agent for SCLC.


Subject(s)
Antineoplastic Agents/pharmacology , Curcumin/pharmacology , Janus Kinases/metabolism , Lung Neoplasms/metabolism , STAT3 Transcription Factor/metabolism , Signal Transduction/drug effects , Small Cell Lung Carcinoma/metabolism , Cell Cycle/drug effects , Cell Line, Tumor , Cell Movement/drug effects , Cell Proliferation/drug effects , Cyclin B1/genetics , Humans , Interleukin-6/pharmacology , Lung Neoplasms/genetics , Lung Neoplasms/pathology , Matrix Metalloproteinases/metabolism , Neovascularization, Pathologic , RNA Interference , STAT3 Transcription Factor/genetics , Small Cell Lung Carcinoma/genetics , Small Cell Lung Carcinoma/pathology
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