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Article in English | MEDLINE | ID: mdl-12174294

ABSTRACT

This paper reported the syntheses of amphiphilic substituted metal phthalocyanines containig sulfonic acid groups and phthalimidomethyl groups (MPcSP, M=Zn or Al(OH), S=-SO(3)(-), P=phthalimidomethyl). We have selected zinc phthalocyanine (Zn-D) as the one with better cell killing potential by an in vitro cell survival assay. Over 90 % tumor cells were killed with 10 mg/L Zn-D, after they were exposed to 12 J/cm(2) red light.

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