ABSTRACT
Three new epipolythiodioxopiperazines, chaetocochins A (1), B (2), and C (3), along with dethio-tetra (methylthio) chetomin (4) and chetomin (5), were isolated from the ethyl acetate extract of the solid-state fermented rice culture of the fungus Chaetomium cochliodes. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1, 3, and 4 exhibited significant cytotoxicity in vitro against cancer cell lines Bre-04, Lu-04, and N-04.
Subject(s)
Antineoplastic Agents , Chaetomium/chemistry , Indole Alkaloids , Oryza/microbiology , Piperazines , Antineoplastic Agents/chemistry , Antineoplastic Agents/isolation & purification , Antineoplastic Agents/pharmacology , Cell Line, Tumor , Drug Screening Assays, Antitumor , Drugs, Chinese Herbal , Humans , Indole Alkaloids/chemistry , Indole Alkaloids/isolation & purification , Indole Alkaloids/pharmacology , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Piperazines/chemistry , Piperazines/isolation & purification , Piperazines/pharmacologyABSTRACT
[structure: see text] Chaetoindicins A-C (1-3), three isoquinolines with novel skeletons, were isolated from the solid-state fermented culture of Chaetomiumindicum. Their structures were elucidated on the basis of spectral data. X-ray crystallographic analysis confirmed the structure of 2.
Subject(s)
Alkaloids/isolation & purification , Chaetomium/chemistry , Isoquinolines/isolation & purification , Alkaloids/chemistry , Crystallography, X-Ray , Isoquinolines/chemistry , Molecular Conformation , Molecular StructureABSTRACT
Four new sesterterpenoids, terretonins A-D (1-4), and a new alkaloid, asterrelenin (5), together with five known compounds, were isolated from the ethyl acetate extract of a solid-state fermented culture of Aspergillus terreus. Their structures were elucidated on the basis of spectroscopic analysis. The structures of 1, 2, and 5 were confirmed by X-ray crystallographic analysis.
