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1.
Nat Commun ; 11(1): 3744, 2020 07 27.
Article in English | MEDLINE | ID: mdl-32719346

ABSTRACT

Epilepsy and autism spectrum disorders (ASD) are two distinct brain disorders but have a high rate of co-occurrence, suggesting shared pathogenic mechanisms. Neuroligins are cell adhesion molecules important in synaptic function and ASD, but their role in epilepsy remains unknown. In this study, we show that Neuroligin 2 (NLG2) knockout mice exhibit abnormal spike and wave discharges (SWDs) and behavioral arrests characteristic of absence seizures. The anti-absence seizure drug ethosuximide blocks SWDs and rescues behavioral arrests and social memory impairment in the knockout mice. Restoring GABAergic transmission either by optogenetic activation of the thalamic reticular nucleus (nRT) presynaptic terminals or postsynaptic NLG2 expression in the thalamic neurons reduces the SWDs and behavioral arrests in the knockout mice. These results indicate that NLG2-mediated GABAergic transmission at the nRT-thalamic circuit represents a common mechanism underlying both epileptic seizures and ASD.


Subject(s)
Behavior, Animal , Cell Adhesion Molecules, Neuronal/metabolism , Epilepsy, Absence/metabolism , Epilepsy, Absence/physiopathology , GABAergic Neurons/metabolism , Nerve Net/physiopathology , Nerve Tissue Proteins/metabolism , Synaptic Transmission , Thalamus/physiopathology , Action Potentials , Animals , Anxiety/physiopathology , Electrodes , Electroencephalography , Electromyography , Ethosuximide , Intralaminar Thalamic Nuclei/physiopathology , Locomotion , Memory , Mice, Inbred C57BL , Mice, Knockout
2.
Mol Brain ; 10(1): 10, 2017 04 07.
Article in English | MEDLINE | ID: mdl-28385162

ABSTRACT

Human studies demonstrate that sleep impairment is a concurrent comorbidity of autism spectrum disorders (ASD), but its etiology remains largely uncertain. One of the prominent theories of ASD suggests that an imbalance in synaptic excitation/inhibition may contribute to various aspects of ASD, including sleep impairments. Following the identification of Nlgn3R451C mutation in patients with ASD, its effects on synaptic transmission and social behaviours have been examined extensively in the mouse model. However, the contributory role of this mutation to sleep impairments in ASD remains unknown. In this study, we showed that Nlgn3R451C knock-in mice, an established genetic model for ASD, exhibited normal duration and distribution of sleep/wake states but significantly altered electroencephalography (EEG) power spectral profiles for wake and sleep.


Subject(s)
Autism Spectrum Disorder/genetics , Autism Spectrum Disorder/physiopathology , Cell Adhesion Molecules, Neuronal/genetics , Electroencephalography , Membrane Proteins/genetics , Mutation/genetics , Nerve Tissue Proteins/genetics , Animals , Disease Models, Animal , Electromyography , Male , Mice, Mutant Strains , Sleep, REM/physiology , Time Factors , Wakefulness/physiology
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