ABSTRACT
AIM: The simplified preparative method and formulation for atenolol monolithic osmotic pump tablets were investigated. METHODS: The core tablets with an indentation were compressed by the punch with a needle. Osmotic pump tablets were prepared by coating the indented tablets. Similarity factor was used to evaluate formulation of osmotic pump tablets. RESULTS: The formulation of core tablets and the composition and thickness of coating membrane showed marked effects on drug release. Orifice size of core tablets in the range of 1.00 - 1.14 mm scarcely affected drug release. CONCLUSION: The preparation of osmotic pump tablets was simplified with the exempting of laser drilling. The atenolol monolithic osmotic pump tablets could deliver drug constantly for 24 h.
Subject(s)
Adrenergic beta-Antagonists/administration & dosage , Atenolol/administration & dosage , Polyethylene Glycols/chemistry , Technology, Pharmaceutical/methods , Adrenergic beta-Antagonists/chemistry , Atenolol/chemistry , Delayed-Action Preparations , Drug Carriers , Osmosis , TabletsABSTRACT
AIM: To study sandwiched osmotic pump tablet for delivering water-insoluble drug for 24 hours. METHODS: Sandwiched osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various formulation variables and orifice size on drug release were studied. The mechanical properties of cellulose acetate membrane were also investigated. RESULTS: Polyethylene oxide of drug layer and potassium chloride of push layer showed marked positive effects on drug release. In the range of 0.50 mm to 1.40 mm, orifice size hardly affects drug release. Cellulose acetate membrane is strong enough to assure the integrity of osmotic pump tablet and could sustain an internal pressure ranging from 0.34 MPa to 2.85 MPa. CONCLUSION: Sandwiched osmotic pump tablet can deliver water-insoluble drug constantly for 24 hours. Release media and agitation rate scarcely affect drug release. Compared with the commercialized push-pull osmotic pump tablet, sandwiched osmotic pump tablet is easy in preparation with exempting identification of drug layer before drilling.
Subject(s)
Cellulose/analogs & derivatives , Nifedipine/administration & dosage , Technology, Pharmaceutical/methods , Cellulose/chemistry , Delayed-Action Preparations , Drug Carriers , Osmosis , Polyethylene Glycols/chemistry , Potassium Chloride/chemistry , Solubility , TabletsABSTRACT
AIM: To study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours. METHODS: Unitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied. RESULTS: Polyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release. CONCLUSION: Unitary-core osmotic pump tablet is very easy in preparation and it can deliver water-insoluble drug in substantially constant rate for 24 hours.
