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Biotechnol Appl Biochem ; 53(Pt 2): 133-7, 2009 Jun.
Article in English | MEDLINE | ID: mdl-18699775

ABSTRACT

A total of 39 microbes were screened for the ability to selectively N-demethylate (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)aminopyrimidin-5-yl)-3,5-dihydroxy-hept-6-enoic acid (I), a potential drug for lowering blood cholesterol levels. Two Streptomyces species were found to carry out the desired N-demethylation. Bioconversion by Streptomyces griseus A.T.C.C. 13273 and product recovery were scaled up to the multi-gram level.


Subject(s)
Bacteria/metabolism , Fungi/metabolism , Pyrimidines/metabolism , Triazoles/metabolism , Biotransformation , Methylation , Streptomyces/metabolism
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