Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Publication year range
1.
Nanomedicine ; 14(4): 1227-1236, 2018 06.
Article in English | MEDLINE | ID: mdl-29458214

ABSTRACT

Dental pulp stem cells (DPSCs) derived from the human dental pulp tissue have multiple differentiation capabilities, such as osteo/odontogenic differentiation. Therefore, DPSCs are deemed as ideal stem cell sources for tissue regeneration. As new nanomaterials based on DNA, tetrahedral DNA nanostructures (TDNs) have tremendous potential for biomedical applications. Here, the authors aimed to explore the part played by TDNs in proliferation and osteo/odontogenic differentiation of DPSCs, and attempted to investigate if these cellular responses could be driven by activating the canonical Notch signaling pathway. Upon exposure to TDNs, proliferation and osteo/odontogenic differentiation of DPSCs were dramatically enhanced, accompanied by up regulation of Notch signaling. In general, our study suggested that TDNs can significantly promote proliferation and osteo/odontogenic differentiation of DPSCs, and this remarkable discovery can be applied in tissue engineering and regenerative medicine to develop a significant and novel method for bone and dental tissue regeneration.


Subject(s)
Dental Pulp/cytology , Nanostructures/chemistry , Stem Cells/cytology , Tissue Engineering/methods , Adolescent , Adult , Blotting, Western , Cell Differentiation/physiology , Cell Proliferation/genetics , Cell Proliferation/physiology , Cells, Cultured , Female , Flow Cytometry , Humans , Male , Odontogenesis/genetics , Odontogenesis/physiology , Signal Transduction/genetics , Signal Transduction/physiology , Young Adult
2.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 46(1): 87-9, 98, 2015 Jan.
Article in Chinese | MEDLINE | ID: mdl-25807802

ABSTRACT

OBJECTIVE: To determine adhesion of Streptococcus mutans (S. mutans) to different kinds of removable denture crowns for the purpose of minimizing influence of removable denture on oral environment. METHODS: Three kinds of removable denture crowns (single color synthetic resin teeth, alloy pin porcelain tooth and minute color synthetic resin teeth) were adsorbed S. mutans for 24 h in sterile saliva, The adhered bacteria were counted by means of sonic oscillation and bacteria coating. RESULTS: Highest level of adhesion was found on ,the single color synthetic resin teeth was adsorbed mostly, followed by alloy pin porcelain teeth. Minute color synthetic resin teeth had far less adhesion than the others (P<0.01). CONCLUSION: Minute color synthetic resin teeth have less adhesion of S. mutans, which may be associated with their lower level of surface free energy.


Subject(s)
Bacterial Adhesion , Crowns/microbiology , Streptococcus mutans , Dental Porcelain , Denture, Partial/microbiology , Surface Properties , Tooth, Artificial/microbiology
SELECTION OF CITATIONS
SEARCH DETAIL
...