1.
Chem Commun (Camb)
; 52(46): 7380-3, 2016 May 31.
Article
in English
| MEDLINE
| ID: mdl-27188496
ABSTRACT
A C2 symmetric small molecule composed of l-phenylalanine and isophthalamide was found to function as a Cl(-)/HCO3(-) dual transporter and self-assemble into chloride channels. In Ussing-chamber based short-circuit current measurements, this molecule elicited chloride-dependent short-circuit current (Isc) increase in both Calu-3 cell and CFBE41o-cell (with F508del mutant CFTR) monolayers.