ABSTRACT
In the title compound, C(19)H(15)Cl(2)O(2)P, the dihedral angle between the mean planes of the phenyl rings bonded to the P atom is 75.4â (1)°. In the crystal, mol-ecules are linked into chains running along the a axis by inter-molecular O-Hâ¯O hydrogen bonds. Mol-ecules are further connected into a three-dimensional array by weak C-Hâ¯O inter-actions.
ABSTRACT
In the title compound, C(19)H(16)NO(4)P, the dihedral angle between the mean planes of the phenyl rings bonded to the P atom is 75.4â (1)°. In the crystal, mol-ecules are linked into chains running along the a axis by inter-molecular O-Hâ¯O hydrogen bonds. Mol-ecules are further connected into a three-dimensional array by weak C-Hâ¯O hydrogen bonds.
ABSTRACT
Six photosensitive polyketides, malbranpyrroles A-F, were discovered from the thermophilic fungus Malbranchea sulfurea by using intact-cell desorption/ionization on silicon mass (ICD-MS) and LC-SPE-NMR. These two strategies facilitate the searching and structural determination of unstable natural products. The ICD-MS indicated that only brown hyphae of M. sulfurea can produce malbranpyrroles. The biosynthetic pathway of malbranpyrroles was evidenced by 13C isotope precursors and amino acid feeding experiments. The cytotoxicity data revealed that the conformation of the conjugated system in malbranpyrroles does not affect cytotoxic potency against cancer cell lines. In addition, the chlorine atom was shown to be the pharmacophore for cytotoxicity.
Subject(s)
Biological Products/chemistry , Chromatography, High Pressure Liquid , Fungi/chemistry , Macrolides/chemistry , Magnetic Resonance Spectroscopy , Mass Spectrometry , Pyrroles/chemistry , Solid Phase Extraction , Biological Products/toxicity , Cell Line, Tumor , Humans , Macrolides/toxicity , Molecular Conformation , Pyrroles/toxicityABSTRACT
The title compound, C(19)H(16)ClO(2)P, was obtained by the reaction of diphenyl-phosphine oxide with 2-chloro-benzaldehyde. The mol-ecule has a tetra-hedral structure at the P atom. The dihedral angle between the phenyl rings attached to the P atom is 80.4â (1)°. The mol-ecules are linked together by inter-molecular O-Hâ¯O and C-Hâ¯O hydrogen-bonding inter-actrions. The crystal studied was an inversion twin.
