Analysis of Relationships Between Prethrombotic States and Cervical Cancer.

OBJECTIVE: To analyze the relationship between a prethrombotic state and the occurrence of thrombosis, as well as survival time for patients with cervical cancer. METHODS: Patients with first diagnosis of cervical cancer were subgrouped according to FIGO staging, and two D-dimer levels were assessed. According to the results, patients are divided into an observation group (abnormal) and control group (normal). RESULTS: For 106 patients with cervical cancer, 38 with abnormal D-dimer, the abnormal rate is 35.9%, of which stage I accounted for 6.5%, stageII 38.5%, stage III 50%, and stage IV 61.1% (p=0.013); The level of D-dimers in stageI wass 0.87±0.68ug/ ml, while in stage II it was 1.50±1.35ug/ml, stage III 2.60±1.86ug/ml and stage IV 18.6±53.4ug/ml (P=0.031); after follow-up of patients for 2-30 months, the mortality of observation group is 21.1%, while for control group it was 2.94% (p <0.01). In the observation group, survival time was 15.1±5.8 months, while for control group it was 21.0±5.4 months, the difference between two groups being highly significant (p=0.000). CONCLUSION: There is a direct correlation between prethrombotic state and the grade malignancy of cervical cancer. The level is positively correlated with clinical stage, and is inversely related to survival time, so that a prethrombotic state could be used to predict the prognosis for patients with cervical cancer.

Analysis of Prethrombotic States in Patients with Malignant Tumors.

BACKGROUND: This study aimed to investigate the incidence and risk factors for a prethrombotic state in patients with malignant tumors. MATERIALS AND METHODS: Plasma d-dimer (D-D) in patients with malignant tumors was measured. Abnormal rates of D-D and possible risk factors like gender, age, type of tumor, and staging of tumor were analyzed. RESULTS: Of 1,453 patients, 629 demonstrated plasma D-D abnormality (43.3%). The D-D abnormal rate of male patients (n=851, 43.5%) was not statistically significantly different from that for female patients (n=602, 43.0%) (p>0.05). D-D abnormal rate increased with age and was statistically significant among different age groups (p<0.05). Regarding staging of tumor, D-D abnormal rate in patients with phase I was 2.0%, 6.2% in phase II, 47.6% in phase III and 83.1% in phase IV, with statistically significant differences between phase III and II, as well as phase III and IV (p<0.01). CONCLUSIONS: A prethrombotic state was closely related to malignancy of tumors. The risk factors for a prethrombotic state include age and tumor stage.

Intrinsic optical properties and enhanced plasmonic response of epitaxial silver.

Using atomically smooth epitaxial silver films, new optical permittivity highlighting significant loss reduction in the visible frequency range is extracted. Largely enhanced propagation distances of surface plasmon polaritons are measured, confirming the low intrinsic loss in silver. The new permittivity is free of extrinsic spectral features associated with grain boundaries and localized plasmons inevitably present in thermally deposited films.

Phase II study on dose escalating schedule of paclitaxel concurrent with radiotherapy in treating patients with locally advanced non-small cell lung cancer.

OBJECTIVE: To evaluate clinical efficacy of a dose escalating schedule of paclitaxel concurrent with radiotherapy in treating patients with locally advanced non-small cell lung (NSCLC). METHODS: Patients with locally advanced NSCLC were treated with conventional fractionated radiotherapy or three dimensional conformal radiotherapy (3 DCRT), concurrently with a dose escalating schedule of paclitaxel. All patients were divided into three groups, A with paclitaxel 30 mg/m2, B with paclitaxel 60 mg/m2 and C with paclitaxel 90 mg/m2. Paclitaxel was repeated every week for a total of 4 or 6 weeks. RESULTS: Among 109 patients, response rates were 68.8%, 71.1% and 71.8% (p>0.05) for group A (n=32), B (n=38), and C (n=39) respectively. Accordingly, disease control rates were 81.3%, 81.6% and 82.1% (p>0.05). Progression-free survival time was 8.0 ± 5.0 months, 11.6 ± 6.1 months, and 14.8 ± 7.9 months (p<0.05), respectively. Overall survival time was 15. 4 ± 7.6 months, 18.2 ± 8.0 months, and 22.0 ± 7.6 months (p<0.05), one-year survival rates were 62.5%, 73.1% and 90.0% (p>0.05) and two-year survival rates were 31.3%, 38.5% and 50.0% (p<0.05) . Main side-effects were bone marrow suppression, radiation related esophagitis and gastrointestinal reaction. CONCLUSION: In treating patients with NSCLC, concurrent chemoradiotherapy with paclitaxel improves early response compared with conventional fractionated radiotherapy or 3 DCRT. The survival rate was improved with the addition of paclitaxel, but there was an increase in adverse reactions when the dose of paclitaxel was increased.

Homogenization of three-dimensional metamaterial objects and validation by a fast surface-integral equation solver.

A homogenization model is applied to describe the wave interaction with finite three-dimensional metamaterial objects composed of periodic arrays of magnetodielectric spheres and is validated with full-wave numerical simulations. The homogenization is based on a dipolar model of the inclusions, which is shown to hold even in the case of densely packed arrays once weak forms of spatial dispersion and the full dynamic array coupling are taken into account. The numerical simulations are based on a fast surface-integral equation solver that enables the analysis of scattering from complex piecewise homogeneous objects. We validate the homogenization model by considering electrically large disk- and cube-shaped arrays and quantify the accuracy of the transition from an array of spheres to a homogeneous object as a function of the array size. Simulation results show that the fields scattered from large arrays with up to one thousand spheres and equivalent homogeneous objects agree well, not only far away from the arrays but also near them.

A subwavelength plasmonic metamolecule exhibiting magnetic-based optical Fano resonance.

The lack of symmetry between electric and magnetic charges, a fundamental consequence of the small value of the fine-structure constant, is directly related to the weakness of magnetic effects in optical materials. Properly tailored plasmonic nanoclusters have been proposed recently to induce artificial optical magnetism based on the principle that magnetic effects are indistinguishable from specific forms of spatial dispersion of permittivity at optical frequencies. In a different context, plasmonic Fano resonances have generated a great deal of interest, particularly for use in sensing applications that benefit from sharp spectral features and extreme field localization. In the absence of natural magnetism, optical Fano resonances have so far been based on purely electric effects. In this Letter, we demonstrate that a subwavelength plasmonic metamolecule consisting of four closely spaced gold nanoparticles supports a strong magnetic response coupled to a broad electric resonance. Small structural asymmetries in the assembled nanoring enable the interaction between electric and magnetic modes, leading to the first observation of a magnetic-based Fano scattering resonance at optical frequencies. Our findings are supported by excellent agreement with simulations and analytical calculations, and represent an important step towards the quest for artificial magnetism and negative refractive index metamaterials at optical frequencies.

Comparative study on transcatheter arterial chemoembolization, portal vein embolization and high intensity focused ultrasound sequential therapy for patients.

OBJECTIVE: To investigate the safety and efficacy of transcatheter arterial chemoembolization (TACE), combined with portal vein embolization (PVE), and high intensity focused ultrasound (HIFU) sequential therapy in treating patients with hepatocellular carcinoma (HCC). METHODS: Patients with inoperative HCC were treated by two methods: in the study group with TACE first, then PVE a week later, and then TACE+PVE every two months as a cycle, after 2~3 cycles finally HIFU was given; in the control group only TACE+PVE was given. Response (CR+PR), and disease control rate (CR+PR+SD), side effects, overall survival and time to progress were calculated. RESULTS: Main side effects of both groups were nausea and vomiting. No treatment related death occurred. In the study group, 32 patients received TACE for overall 67 times, PVE 64 times, and HIFU 99 times; on average 2.1, 2 and 3.1 times for each patient, respectively. In the control group, 36 patients were given TACE 78 times and PVE 74 times, averaging 2.2 and 2.1 times per patient. Effective rate: 25.0% in study group and 8.3% in control group (p>0.05). Disease control rates were 71.9% and 44.4%, respectively (p<0.05). In patients with portal vein tumor thrombus, the rate reduced over 1/2 after treatment was 69.2%(9/13) in the study and 21.4%(3/14) in the control group (p<0.05). Rate of AFP reversion or decrease over 1/2 was 66.7%(16/24) in study and 37%(10/27) (p<0.05) in control group. Median survival time: 16 months in study and 10 months in control group. PFS was 7months in study and 3 months in control group. Log-rank test suggested that statistically significant difference exists between two groups (p=0.024). 1-, 2- and 3-year survival rates were 56.3%, 18.8% and 9.3% in study, while 30.6%, 5.6% and 0 in control group, respectively, with statistically significant difference between two groups (by Log-rank, p = 0.014). CONCLUSIONS: The treatment of TACE+PVE+HIFU sequential therapy for HCC increases response rate, prolong survival, and could thus be a safe and effective treatment for advanced cases.

Dispersion mechanism of surface magnetoplasmons in periodic layered structures.

We investigate the dispersion mechanism of surface magnetoplasmons for periodic layered structures in the Voigt configuration. An analytical dispersion relation that retains a similar form with ordinary surface plasmons is obtained. The splitting of surface plasma frequency is accompanied with unequal field strengths of surface modes at the two interfaces and is characterized by a simple dynamic model that recasts the role of magnetic force on to the effective mass. The underlying mechanism is illustrated with the transverse currents induced by the cyclotron motion of electrons, which appears as the typical feature of the dynamic Hall effect. In particular, the acoustical and optical branches exhibit an anticrossing scheme for small filling fractions, due to the like symmetry of modes in the two branches. As the parallel wave number changes, the two interaction branches experience a transition of mode pattern from symmetry to antisymmetry, or vice versa.

Particle plasmons of metal nanospheres: application of multiple scattering approach.

In this paper, we study particle plasmons associated with a chain of metal nanospheres by the method of multiple scattering. The extinction efficiency is used to identify the resonant modes in nanoparticle chains. Special emphasis is placed upon the multipolar nature of particle plasmons at two major resonant modes by studying the associated field patterns, surface charges, and distributions of the field enhancement. Effects of the number of particles, interparticle spacing, and particle alignment are investigated by examining the frequency shift, bandwidth, and the number of resonant modes.

[SNaPshot technique for detection of single-nucleotide polymorphisms (SNPs) in HBV polymerase gene region of HBV gene].

OBJECTIVE: To establish a rapid specific method to identify the single-nucleotide polymorphisms (SNPs) of HBV polymerase gene region which are the methionine residue of the conserved YMDD motif. METHODS: Two specific primers were designed to amplify interested gene region involved in SNPs which were also used as HBV DNA identification. Specific primers of SNaPshot were designed to detect 741A-G (YVDD), 743G-T (YIDD). The different fluorescent dye labeled ddNTP was used to further extend the strand of PCR product and was detected by ABI PRISM 310 Genetic Analyzer. Sera from 13 patients with chronic hepatitis B after lamivudine treatment were analyzed. RESULTS: Aside from mutation of YMDD, there were mutations of 514C-A, 523C-A, 562T-A, 667C-A. The 13 samples were simultaneously tested with SNaPshot and DNA sequencing, the same results were obtained. The method of SNaPshot showed high specificity. CONCLUSION: Mutation of YMDD results in the changes of ATG codon, and there are new ATG codon in the upper strand of YMDD. SNaPshot technique is rapid, specific and accurate for the SNPs monitoring of HBV DNA mutation during lamivudine therapy. Two samples were determined by SnaPshot technique, identifying the co-existence of the mixed wild type and mutant type HBV infection.