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J Clin Pharm Ther ; 35(6): 729-32, 2010 Dec.
Article in English | MEDLINE | ID: mdl-21054466

ABSTRACT

Hypersensitivity syndrome associated with teicoplanin has rarely been reported. We report a case with a preceding episode of vancomyin-related neutropenia. A 47-year-old female with cervical spine infection was treated with vancomycin. Neutropenia occurred after 17 days of vancomycin therapy. Vancomycin was changed to teicoplanin, and the neutropenia resolved 4 days later. After 11 days of teicoplanin therapy, a new episode of hypersensitivity syndrome manifested as fever, bilateral neck lymphadenopathy, mild wheezing, hepatitis and increased CRP occurred. Neutropenia and thrombocytopenia developed 3 days later. The patient's symptoms settled over 1 week following withdrawal of teicoplanin. Naranjo's ADR algorithm categorized the neutropenia associated with vancomycin and the hypersensitivity syndrome associated with teicoplanin as 'probable'.


Subject(s)
Anti-Bacterial Agents/adverse effects , Drug Hypersensitivity/etiology , Neutropenia/chemically induced , Teicoplanin/adverse effects , Vancomycin/adverse effects , Anti-Bacterial Agents/therapeutic use , Female , Fever/drug therapy , Fever/etiology , Humans , Infections/drug therapy , Middle Aged , Spinal Diseases/drug therapy , Teicoplanin/therapeutic use , Vancomycin/therapeutic use
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