ABSTRACT
Stabilized composition of alpha-2-macroglobulin retains its physico-chemical and biological properties for 1 year storage at (6 +/- 2) degrees C. During this term it does not change its anticomplement activity, i.e. the alpha-2-macroglobulin concentrate with the stabilizer is safe for the body and ready for intravenous administration.
Subject(s)
Complement Inactivator Proteins/chemistry , alpha-Macroglobulins/chemistry , Animals , Chemical Phenomena , Chemistry, Physical , Complement Inactivator Proteins/administration & dosage , Complement Inactivator Proteins/analysis , Drug Stability , Drug Storage , Humans , Injections, Intravenous , Rabbits , Solutions , Time Factors , alpha-Macroglobulins/administration & dosage , alpha-Macroglobulins/analysisABSTRACT
The author reports results of examination for sterility of 3100 series (7343 samples) of hemocorrectors that were received for State control from zonal blood transfusion stations in the Ukraine from 1987 through 1990. Four of them proved non-sterile. Strict surveillance for aseptics and antiseptics at all stages of the technological process will ensure sterility of all hemotransfusion media obtained from the blood transfusion services.