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1.
Vopr Onkol ; 60(3): 348-51, 2014.
Article in Russian | MEDLINE | ID: mdl-25033689

ABSTRACT

There was performed a comparative analysis of quantitative load and physical status of human papillomavirus (HPV) type 16 in groups of patients with cervical intraepithelial neoplasia (CIN)--25 people and cervical cancer (CC)--85 people. According to the analysis there were selected criteria appropriate to a combination of adverse factors that characterized HPV- infection and at the same time estimated both quantitative load and physical status of the virus: high viral load (> 6,5 lg copies of HPV DNA per 100000 cells) in episomal form or low load (< 6,5 lg copies of HPV DNA per 100000 cells) in integrated form of the virus. According to calculations a relative chance of appearing of CC in CIN patients with unfavorable combination of factors was 7,5 times higher than in other patients.


Subject(s)
Cell Transformation, Neoplastic , Cervix Uteri/pathology , Cervix Uteri/virology , Human papillomavirus 16/isolation & purification , Papillomavirus Infections/complications , Uterine Cervical Dysplasia/virology , Uterine Cervical Neoplasms/virology , Adult , Aged , DNA, Viral/isolation & purification , Female , Human papillomavirus 16/genetics , Humans , Middle Aged , Neoplasm Staging , Papillomavirus Infections/virology , Prognosis , Risk , Uterine Cervical Neoplasms/pathology , Viral Load
2.
Vopr Onkol ; 59(6): 756-60, 2013.
Article in Russian | MEDLINE | ID: mdl-24624787

ABSTRACT

For the 83 patients with HPV 16-cancer of the cervix (cervical cancer) I-III stages it was performed a comparative analysis of primary tumor response to therapy, the clinical outcome of the disease for 3-5 years after radical treatment and an evaluation of the possible contribution in these rates of the physical status of the virus. It was shown that total tumors regression in the early stages of the observation predominate in patients with "high-integrated" virus DNA (the degree of integration > 50%) of compared with a group of patients with episomal and "low-integrated" form of the virus, but in a distant periods (3-5 years) in the first group predominate an adverse outcome of disease. This pattern is true for tumors of stage I-III, and for less common--I-II stages. It is assumed that the integration of HPV16 DNA into the cellular genome may serve as an independent predictor of clinical outcome of cervical cancer.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Chemoradiotherapy , Genome, Human , Human papillomavirus 16/pathogenicity , Papillomavirus Infections/complications , Uterine Cervical Neoplasms/pathology , Uterine Cervical Neoplasms/therapy , Adult , Aged , Comparative Effectiveness Research , DNA, Viral/analysis , Disease-Free Survival , Female , Fluorouracil/administration & dosage , Human papillomavirus 16/genetics , Humans , Middle Aged , Neoplasm Invasiveness , Neoplasm Staging , Papillomavirus Infections/virology , Platinum Compounds/administration & dosage , Polymerase Chain Reaction , Predictive Value of Tests , Prognosis , Treatment Outcome , Uterine Cervical Neoplasms/diagnosis , Uterine Cervical Neoplasms/virology
3.
Vopr Onkol ; 56(2): 185-90, 2010.
Article in Russian | MEDLINE | ID: mdl-20552895

ABSTRACT

Real-time polymerase chain reaction procedure was used to evaluate bioptic tumor samples from patients suffering cervical carcinoma (CC) stages I-IV. Out of 110 patients, high-risk human papillomavirus (HPV) infection was identified in 98 (89.1%), HPV type 16--63, HPV type 18--10 and HPV type 45--5. One of genotypes 31.33, 35, 39, 52, 58, 59 was established in 8 and a combination of several genotypes of the virus--12 patients. Frequency of remission in CC patients associated with HPV type 16 who had survived 3 years was significantly higher than in the same category associated with HPV type 18 (p=0.03). Relapse frequency and mortality rates in patients with tumors associated with one of viruses 31.33, 35, 39, 52, 58 or 59 were higher as compared with HPV type 16--associated cases 2 years (p=0.03) or 3 years on (p=0.11), respectively. A similar trend was established for squamous-cell tumors stages 1 and 2 (p=0.07) (p=0.12), respectively. No difference was observed in efficacy of therapy for infection with one or a combination of several genotypes of high-risk HPV. Hence, the genotype of virus is believed to be a factor of prognosis in CC early cancers. However, a definitive conclusion cannot be reached until results of a larger body of evidence and longer follow-up are available.


Subject(s)
Alphapapillomavirus/isolation & purification , Papillomavirus Infections/complications , Tumor Virus Infections/complications , Uterine Cervical Neoplasms/virology , Adult , Aged , Alphapapillomavirus/genetics , DNA, Viral/isolation & purification , Female , Genotype , Human papillomavirus 16/isolation & purification , Human papillomavirus 18/isolation & purification , Humans , Middle Aged , Papillomavirus Infections/virology , Polymerase Chain Reaction , Prognosis , Risk Factors , Tumor Virus Infections/virology
4.
Patol Fiziol Eksp Ter ; (4): 17-8, 2007.
Article in Russian | MEDLINE | ID: mdl-18159640

ABSTRACT

Noninbred rat experiments with M-1 tumor have found that combination of fenylin with photodynamic therapy produced a 1.5-fold slowing down in the growth of the tumor compared to the control animals on day 15 and 21 after the treatment.


Subject(s)
Anticoagulants/therapeutic use , Neoplasms/drug therapy , Phenindione/therapeutic use , Photochemotherapy/methods , Animals , Anticoagulants/pharmacology , Cell Line, Tumor , Hemostasis/drug effects , Phenindione/pharmacology , Rats , Xenograft Model Antitumor Assays
5.
Patol Fiziol Eksp Ter ; (3): 32-4, 1996.
Article in Russian | MEDLINE | ID: mdl-8966053

ABSTRACT

The purpose of this work was to examine the relationship between the antiaggregatory activity of the vascular wall and the metastatic spread of experimental tumors. Rats with the tumor "Myosarcoma-1" displayed, on the average, a 30% reduction in the antiaggregatory activity of the aortic wall. Three-week of the animals with a combination of the drugs dipyridamole (0.84 mg/kg per os), phytin (14 mg/kg per os), glutamic acid (28 mg/kg per os) restored the antiaggregatory properties of the vascular wall virtually up to the control values. The similar result was observed with cordarone (60 mg/kg intraperitoneally): the antiaggregatory properties of the vascular wall increased on the average by 50%. The metastatic spread of tumor cells in mice with Lewis carcinoma of the lung decreased on the average twice while treating them with these agents. The findings point to the fact that drug correction of the antiaggregatory activity of the vascular wall reduces the rate of metastatic spread.


Subject(s)
Endothelium, Vascular/physiology , Fibrinolysis/physiology , Neoplasms, Experimental/physiopathology , Animals , Female , Male , Mice , Mice, Inbred C57BL , Neoplasms, Experimental/secondary , Rats
7.
Radiats Biol Radioecol ; 33(5): 694-9, 1993.
Article in Russian | MEDLINE | ID: mdl-8293095

ABSTRACT

Exposure of hen's eggs to irradiation by doses 0.05-1.66 Gy (dose rate 2.56x10-4 Gy/s) in early embryonal period (1st day of incubation of eggs doesn't essentially affect on indices of functional state of haemostasis system of two-month aged individuals, except the activation of contact phase of blood coagulation, in which a hypercoagulation shift within normal fluctuations has been noted.


Subject(s)
Chick Embryo/radiation effects , Hemostasis/radiation effects , Radiation Dosage , Animals , Animals, Newborn , Chick Embryo/physiology , Chickens , Female , Gamma Rays , Hemostasis/physiology , Male
9.
Biull Eksp Biol Med ; 108(12): 716-8, 1989 Dec.
Article in Russian | MEDLINE | ID: mdl-2634448

ABSTRACT

The influence of tumor (RA-2) growth on the vascular-platelet haemostasis of mongrel rats was studied. The decrease of the antiaggregation properties of vascular wall and high functional activity of platelets with its intravascular aggregation were correlating with processes of tumor growth and dissemination. Anticoagulation activity of vascular wall also decreased. It is suggested that the change detected may play role in the onco-thromboembolic formation, its penetration via vascular wall and metastatic locus development.


Subject(s)
Blood Platelets/physiology , Blood Vessels/physiopathology , Hemostasis/physiology , Neoplasms, Experimental/blood , Adenosine Diphosphate/pharmacology , Animals , Blood Platelets/drug effects , Blood Vessels/drug effects , Hemostasis/drug effects , Male , Neoplasm Metastasis , Neoplasm Transplantation , Platelet Aggregation/drug effects , Platelet Aggregation/physiology , Rats
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