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Bioorg Khim ; 15(6): 748-62, 1989 Jun.
Article in Russian | MEDLINE | ID: mdl-2783173

ABSTRACT

A convenient route of synthesis of amphibian bombesin and bombesin-like peptide alytesin was found. These tetradecapeptides were obtained by assembling the 1-5 and 6-14 fragments by means of DCC-HONB or mixed anhydrides methods. Structure of the tetradecapeptides was confirmed by high resolution NMR spectroscopy data. The bombesin and alytesin synthesized potently decrease body temperature and stimulate pancreatic juice secretion.


Subject(s)
Bombesin/chemical synthesis , Peptides/chemical synthesis , Amino Acid Sequence , Animals , Anura , Chromatography, Ion Exchange , Magnetic Resonance Spectroscopy , Molecular Sequence Data
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