Progresses of the correlation between viral myocarditis and genetic polymorphisms in children / 国际儿科学杂志

The pathogenesis of viral myocarditis(VMC)still remains uncertain.The direct viral damage to heart muscle cells,the autoimmunity induced by viruses,the gene polymorphism and the genentic susceptibility are involved.Moreover,the symptoms and the prognosis of VMC are various.The relationship between VMC and the relevant gene polymorphism are reviewed in this paper,including coxsackie-adenovirus receptor,vitamin D receptor,human leukocyte antigen,nitric oxide synthase,matrix metalloproteinases,angiotensin converting enzyme and various cytokine.The purpose is to find new breakthroughs on VMC prevention and treatment.