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1.
Opt Express ; 23(9): 11898-911, 2015 May 04.
Article in English | MEDLINE | ID: mdl-25969280

ABSTRACT

This paper investigates experimental means of measuring the transmission matrix (TM) of a highly scattering medium, with the simplest optical setup. Spatial light modulation is performed by a digital micromirror device (DMD), allowing high rates and high pixel counts but only binary amplitude modulation. On the sensor side, without a reference beam, the CCD camera provides only intensity measurements. Within this framework, this paper shows that the TM can still be retrieved, through signal processing techniques of phase retrieval. This is experimentally validated on three criteria : quality of prediction, distribution of singular values, and quality of focusing.

2.
Phys Med Biol ; 60(3): 1069-85, 2015 Feb 07.
Article in English | MEDLINE | ID: mdl-25585885

ABSTRACT

Transcranial focused ultrasound is a promising therapeutic modality. It consists of placing transducers around the skull and emitting shaped ultrasound waves that propagate through the skull and then concentrate on one particular location within the brain. However, the skull bone is known to distort the ultrasound beam. In order to compensate for such distortions, a number of techniques have been proposed recently, for instance using Magnetic Resonance Imaging feedback. In order to fully determine the focusing distortion due to the skull, such methods usually require as many calibration signals as transducers, resulting in a lengthy calibration process. In this paper, we investigate how the number of calibration sequences can be significantly reduced, based on random measurements and optimization techniques. Experimental data with six human skulls demonstrate that the number of measurements can be up to three times lower than with the standard methods, while restoring 90% of the focusing efficiency.


Subject(s)
Brain Diseases/therapy , High-Intensity Focused Ultrasound Ablation/methods , Magnetic Resonance Imaging/methods , Skull/diagnostic imaging , Skull/pathology , Ultrasonic Therapy/methods , Brain Diseases/pathology , Calibration , Humans , Phantoms, Imaging , Radiography , Transducers , Ultrasonic Therapy/instrumentation
3.
Sci Rep ; 4: 5552, 2014 Jul 09.
Article in English | MEDLINE | ID: mdl-25005695

ABSTRACT

The recent theory of compressive sensing leverages upon the structure of signals to acquire them with much fewer measurements than was previously thought necessary, and certainly well below the traditional Nyquist-Shannon sampling rate. However, most implementations developed to take advantage of this framework revolve around controlling the measurements with carefully engineered material or acquisition sequences. Instead, we use the natural randomness of wave propagation through multiply scattering media as an optimal and instantaneous compressive imaging mechanism. Waves reflected from an object are detected after propagation through a well-characterized complex medium. Each local measurement thus contains global information about the object, yielding a purely analog compressive sensing method. We experimentally demonstrate the effectiveness of the proposed approach for optical imaging by using a 300-micrometer thick layer of white paint as the compressive imaging device. Scattering media are thus promising candidates for designing efficient and compact compressive imagers.

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