ABSTRACT
The comparative study of the humoral and cellular characteristics of antimeasles immunity in children immunized with live measles vaccine Ji-16, and in children having had measles revealed that both "wild" and vaccine strains of measles virus induced similar changes in the organism of the child: the synthesis of specific antibodies belonging to different physico-chemical classes, changes in the content of different serum immunoglobulins and the suppression of the blastogenic response of peripheral blood lymphoyctes to phitohemagglutinins. The changes suggest that both T- and B-lymphocytes took part in the formation of antimeasles immunity, but all these processes were more pronounced during the formation of postinfection immunity.
Subject(s)
Antibodies, Viral/biosynthesis , Measles/prevention & control , Vaccination , B-Lymphocytes/immunology , Child, Preschool , Hemagglutination Inhibition Tests , Humans , Immunoglobulin A/biosynthesis , Immunoglobulin G/biosynthesis , Immunoglobulin M/biosynthesis , Infant , Lymphocyte Activation , Measles/immunology , Phytohemagglutinins/pharmacology , T-Lymphocytes/immunologyABSTRACT
The dynamics of the total content of measles antibody with reference to their physico-chemical nature and the dynamics of the content of the main classes of serum immunoglobulins (A, M, G) in children previously vaccinated and not vaccinated with live measles vaccine who developed measles were studied. Measles in the vaccines was found to run a course of the type of primary and secondary infection. In the former case, the normal dynamics of specific antibody was found with timely change of synthesis of antibody of various physico-chemical nature. In the latter case, immunity to measles developed according to the secondary type and was characterized by the absence of IgM measles antibody. The secondary immunological response was also characterized by higher antibody titers in the first days of the disease and decreased content of IgG and IgM in sera in the convalescent stage. Besides, in such children, hyperthermia occurred 3 times less frequently.
