[Myocardial involvement in hyper- and hypothyroidism]. / O porazhenii miokarda pri giper- i gipotireoze.

The paper is devoted to early myocardial pathology in patients with hyper- and hypothyroidism (15 patients with diffuse toxic goiter and 18 patients with primary hypothyroidism). They were investigated by radionuclide scintigraphy of the myocardium with -201TlCl. The myocardium in thyroid pathology was shown to suffer from dystrophic disorders, determined by metabolic derangements. The absence of disturbed perfusion processes in the myocardium and a diffuse decrease in metabolic activity of cardiomyocytes were revealed. Similar changes were found in patients without signs of myocardial involvement on ECG.

[Study of the effect of arterial hypertension on the status of left- ventricular myocardium based on thallium-201 scintigraphic data]. / Vliianie arteria'lnoi gipertenzii na sostoianie miokarda levogo zheludochka po dannym stsintigrafii c 201Tl.

Functional relationship was examined between the parameters of myocardial perfusion, left ventricular myocardial mass, and complications developed in patients with coronary heart diseases concomitant with arterial hypertension. Examination was made of 102 patients with various natural history of arterial hypertension, of whom 53 had concomitant angina pectoris, myocardial infarction, congestive heart failure, sudden death, or rhythm disturbances. As "perfusion deficiency" progressed, the patients with complicated natural history of arterial hypertension were found to increase in number with higher left ventricular myocardial mass index. In patients with arterial hypertension, the critical hypertrophy phase in which the index of left ventricular myocardial mass was 110-120 gm2 was demonstrated to be followed by myocardial perfusion deficiency. If the myocardial mass index is 90 g/m2, it means a phase of compensatory hypertrophy, which shows higher myocardial perfusion.

[Radioimmunoassay in the diagnosis of atypical forms of thyrotoxicosis]. / Radioimmunologicheskii analiz v diagnostike atipichnykh form tireotoksikoza.

Fifty-six patients with "unmotivated" disorder of the cardiac rhythm were examined. A combined radionuclide study including a study of iodoabsorptive function with a standard technique, thyroid visualization and determination of the thyroxin triiodothyronine level in the blood serum with the radioimmunoassay using standart diagnostic kits, was conducted. Latent thyroid hyperfunction was revealed in 24 patients (42.8%). Study of iodoabsorptive function revealed pathological changes in 8 patients only, whereas radioimmunoassay revealed a significant elevation of the peripheral thyroid hormone level as compared to that of the control group in 24 patients. Change of the TSH level was not noted. The conclusion is that patients with "unmotivated" disorder of the cardiac rhythm often suffer from latent thyrotoxicosis which is the main etiological factor and trigger mechanism of arrhythmias. In such a situation they are the only clinical symptom of thyrotoxicosis that makes it possible to regard this form of disease as monosymptomatic. The early detection of the cause of cardiac rhythm disorder and the prescription of pathogenetic thyrostatic therapy resulted in the return of the cardiac cycle rate to normal in all the patients with sinus tachycardia and prevented relapses of the paroxysmal forms of rhythm disorder.